Dr. Alan Rosenberg

Alan Rosenberg, BA, MD, FRCPC

Dr. Rosenberg, a pediatric rheumatologist, provides care to Saskatchewan children and youth with various forms of arthritis and related rheumatic diseases. The Pediatric Rheumatology Clinical Program coordinates comprehensive multidisciplinary care at the Royal University Hospital and throughout Saskatchewan via travelling and telehealth clinics. Dr. Rosenberg also provides care for children with immunologic, including immunodeficiency disorders.

Dr. Rosenberg also directs the activities of The Pediatric Rheumatic Disease Research and Innovative Laboratory at the University of Saskatchewan. For more than two decades the Laboratory has maintained an active research program.

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Dr. Joyce Wilson

Joyce Wilson, PhD

Dr. Wilson received her PhD from Queen’s University and postdoctoral training at the University of Georgia and the University of Toronto. She is currently a Professor at the University of Saskatchewan in the department of Biochemistry, Microbiology, and Immunology. Her research focuses on how viruses interact with host miRNA machinery and how viral life cycles are regulated by viral genomic RNA structures. In particular her lab has studied for many years how miR-122, a liver specific miRNA promotes HCV infections. MiR-122 anneals to the HCV 5’ untranslated region in association with the host protein Argonaute 2 and is required for efficient genome replication. It is also an important regulator of HCV tropism to the liver. Recent evidence suggests that miRNA annealing activates a molecular switch by changing the structure of the viral genomic RNA. And her work focuses on discovering how and why the virus became dependent on a host microRNA and characterizing the molecular details of the RNA structural switch. Further,  her work aims to identify RNA structures and molecular switches in other viral genomes to gain a better understanding of how genomic RNA structures regulate virus life cycles. RNA motifs involved in virus replication are in general more conserved and intolerant to mutations making them promising therapeutic targets. Her research is funded by the Canadian Institutes for Health Research (CIHR) and the Natural Sciences and Engineering Council of Canada (NSERC).

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