Cameco MS Neuroscience Research Centre
The Cameco MS Neuroscience Research Centre was established in 1996 with a mandate to support and encourage basic and clinical neuroscience research related to the cause, treatment, and cure of multiple sclerosis, and to support and encourage basic neuroscience research related to the cause, treatment and cure of other neurological disorders.
The primary research facility is housed in Saskatoon City Hospital, created by a partnership of the University of Saskatchewan Colleges of Medicine and Dentistry, the MS Society of Canada (Saskatchewan Division), the Saskatoon Health Region, and the Saskatoon City Hospital Foundation. Major financial support for the Cameco MS Neuroscience Research Centre has been provided by the Quest For A Cure fundraising drive sponsored by the Cameco Corporation.
To learn more, please access the Cameco MS Neuroscience Research Centre website.
Canadian Centre for Health & Safety in Agriculture (CCHSA)
2016 marked the CCHSA’s 30th year of being a world leader in promoting and investigating the health of rural populations. The on-going growth and development of conducting and stimulating research, education, and health promotion programs aimed at enhancing the health and overall well-being of agricultural, rural, and remote populations is made possible by the generous efforts of all contributors including students, researchers, faculty, and staff. The Centre continues to prove itself a living organism as it develops, evolves, and thrives.
To learn more, please access CCHSA's website.
The Canadian Light Source (CLS) is a national research facility owned by the University of Saskatchewan, and one of the largest science projects in Canada’s history, producing the brightest light in the country—millions of times brighter than even the sun.
More than 1,000 academic, government and industry scientists from around the world use the CLS every year, in innovative health, agriculture, environment, and advanced materials research.
The CLS has several experimental facilities that enable world-leading health research, including a biomedical imaging and therapy facility, two protein crystallography beamlines, a mid-infrared facility, and three biological X-ray absorption spectroscopy beamlines. These facilities enable important health research to uncover mechanisms involved in diseases like Parkinson’s, cancer, HIV-1, osteoporosis, cystic fibrosis, multiple sclerosis, heart disease new drug development, antibiotic resistance, malaria, and much more.
Primary access to the CLS is based on peer review, emphasizing the excellence of science where there is intent to publish scientific results. Purchased Access is also available: user time obtained through this mode is determined by contractual agreements between CLSI and the purchaser.
The Canada Foundation for Innovation, Natural Sciences and Engineering Research Council, National Research Council of Canada, Canadian Institutes of Health Research, the Government of Saskatchewan, and the University of Saskatchewan fund our operations.
Indigenous Peoples' Health Research Centre (IPHRC)
IPHRC is focused on building capacity for community-based Indigenous health research in Saskatchewan. Researchers, students, and community members who envision thriving, healthy, self-determining Indigenous peoples, families, and communities come together to create networks of Indigenous health researchers regionally, nationally, and internationally.
To learn more, please visit IPHRC's website.
Protein Characterization & Crystallization Facility (PCCF)
PCCF was established to provide support for researchers whose work benefits from investigation of proteins in vitro. Geared towards the needs of PRISM members (predominantly biologists and biochemists), PCCF is located in the D-wing of the Health Sciences building. While primary users of PCCF are members of PRISM, PCCF is open to all University of Saskatchewan faculty within the available instrument and personnel capacity.
To learn more, please visit PCCF's website.
Phenogenomic Imaging Centre of Saskatchewan (PICS)
Based at the University of Saskatchewan, the PICS centre provides specialist support to help the Saskatchewan scientific community in carrying out high-throughput RNAi and CRISPR screens with human cells. PICS supports both high-content microscopy as well as infrastructure needed to process these samples in a high-throughput fashion. This can either be used to identify genes involved in disease representing future drug targets or to identify genes involved in biological processes.
To learn more, please access the PICS website.
Respiratory Research Centre (RRC)
In 2017, the RRC was collaboratively launched by the U of S College of Medicine and the Lung Association of Saskatchewan. RRC is dedicated to enabling ground-breaking discoveries in respiratory health from across the province.
To learn more, please visit RRC's website.
Saskatchewan Centre for Patient-Oriented Research (SCPOR)
SCPOR is a partnership of organizations that support patient-oriented research in Saskatchewan. SCPOR is also committed to supporting Rural and Indigenous health research in the province. The Indigenous Platform advises and contributes to SCPOR programs and activities to advance SCPOR’s core values and build capacity in Indigenous-specific engagement and research across the province.
To learn more, please access SCPOR's website.
Saskatchewan Population Health & Evaluation Research Unit (SPHERU)
SPHERU is a bi-university health research unit. Bases at both the Universities of Regina and Saskatchewan, SPHERU has established itself as a leader in cutting edge population health research since 1999. SPHERU examines factors that address not only the what and the why of health inequities – but also strategizes plans of action to proactively make a difference in the health of Saskatchewan’s people.
To learn more, please access SPHERU's website.
Clinical Research Support Unit (CRSU)
The CRSU provides multi-faceted research assistance to all faculty members, residents, students, and researchers within the College of Medicine. Investigators across the basic medical, clinical, and population health sciences can access support for study design, sample size/power calculation, data management, analysis, and manuscript revision. Requests to review funding applications are also welcome. Support is provided by doctoral-level biostatisticians and biostatistical graduate students—all at zero cost.
The CRSU assists with 80 to 100 research projects annually at varying stages of development, although engagement early in the research process is encouraged. Support requests can be initiated by completing the CRSU Intake Form.
Please note: given the frequent overlap of multiple requests during peak periods, 2-3 weeks may be required before an initial appointment can be made.
The CRSU aims to contribute towards maximizing the research productivity of the College of Medicine research community. To that end, support is often ongoing in nature, frequently culminating in conference presentation and publication of project findings. CRSU acknowledgment and possibly shared authorship, at the dissemination of results is requested if a significant contribution has been made by CRSU staff.
Departments within the College of Medicine aiming to encourage the development of quantitative research knowledge/skills among their faculty and residents can request academic presentations on related topics of interest by CRSU staff. Basic instruction in the use of SAS (a statistical program frequently used in statistical analysis) is also offered to individuals within the College of Medicine on an annual basis, usually in September/October, for a minimal cost.
Please Contact the CRSU office with inquiries.
Clinical Trial Support Unit (CTSU)
The CTSU helps researchers overcome the administrative, operational, and regulatory hurdles that accompany clinical research. The CTSU handles the start-up activities for a study, ensuring that the contract, budget, regulatory, operational, and ethical approvals are in place so the study can begin. CTSU staff continue to provide support over the full course of the study, ensuring the research is completed correctly, efficiently, and in compliance with regulations. Although the CTSU’s title emphasizes clinical trials, the CTSU assists researchers with all kinds of clinical research.
The CTSU supports both industry-sponsored and investigator-initiated research. If the study involves a budget with a sponsor, every effort is made to ensure the researcher’s costs are covered by the sponsor. If the researcher is initiating their own clinical trial, the CTSU provides the services needed to carry out the trial in compliance with the Food and Drug Regulations. A critical first step is to prepare and submit the Clinical Trial Application to Health Canada. Additional services include case report form design, web-based clinical data management systems (e.g., REDCap), data management plans, monitoring plans, trial monitoring, and project management. The CTSU’s experienced clinical research nurses and clinical research coordinators ensure studies are completed successfully while maintaining regulatory compliance.
There is a cost to use CTSU services. However, for industry-sponsored research, it is usually possible to fully cover the CTSU’s fees in the budget negotiated with the sponsor. Because budgets are typically tighter for non-industry research, the CTSU offers reduced rates for those studies. Contract negotiation services are offered free-of-charge for both industry and non-industry research, regardless of whether the researcher chooses to use the CTSU’s other services.
For more information, contact CTSU director Scott Corley via Email, or phone (306)978-8304.
Healthcare Research and Quality Improvement (HRQI)
HRQI supports vital research to improve clinical decision-making, advance patient safety, decrease medical errors, and enhance health care quality and access. Also, HRQI is uniquely positioned to support best practice research and to help promote its dissemination to improve primary care in Saskatchewan.
HRQI recognizes the importance of research into the science of primary care and patient-centered outcomes. We enthusiastically support these efforts believe that it must continue to have adequate resources to pursue its goals.
The HRQI key areas of focus include:
- Safety and Quality: Reduce the risk of harm by promoting the delivery of the best possible care.
- Effectiveness: Improve health care outcomes by encouraging the use of evidence to make informed health care decisions.
- Efficiency: Transform research into practice to facilitate more extensive access to effective health care service and reduce unnecessary costs.
Evidence-based clinical practice requires HRQI-supported healthcare research in areas such as Practice-Based Research, practice transformation, patient quality, and safety in hospital and non-hospital settings. Saskatchewan's healthcare system relies on research developed to answer key clinical questions based on Saskatchewan’s effective health care program to help clinicians make better treatment choices. HRQI provides the critical evidence reviews needed to answer questions on the common acute, chronic, and comorbid conditions that family physicians see daily. HRQI research also examines health information technology to provide the evidence to inform meaningful use policy and practice so that health IT can be used more effectively to improve the quality of Saskatchewan health care.
Please contact the HRQI office with inquiries.
Research Facilities & Equipment
The Core MS Facility supports research in which mass spectrometry has a significant role. Recent advancements in technology have positioned mass spectrometry as a critical tool for use in the qualitative and quantitative identification of biologically relevant molecules. As a result, there has been exponential growth of projects and applications with direct input stemming from mass spectrometry.
Within the Core MS Facility, sophisticated instruments are housed for the analysis of compounds from small organic molecules to large proteins. Ancillary to that direct application of mass spectrometry are expertise and equipment to aid researchers in their sample preparation and strategies for the appropriate use of MS technologies.
The Common Equipment Core contains shared equipment to support Health Sciences research at the University of Saskatchewan. The Facility provides expert training and assistance in the use of this equipment.
|The Histology Core Facility contains a wide range of histology equipment to support Health Sciences research at the University of Saskatchewan. The Facility provides expert training and assistance in histological techniques and sample processing.||Contact|
The NGSF is located within B128 and has equipment and services available to assist with basic and clinical genetic research and bioinformatics in Health Sciences. The Facility provides expert consultation services and quotations customized to the project needs.
|The PCCF provides expanded support for researchers investigating proteins in vitro. The concept of this facility is to assemble the instrumentation required for protein cloning and expression, purification, characterization, and crystallization, along with providing the necessary expertise to ensure researchers are supported throughout each step in the process. The primary users of PCCF are the members of the PRISM Centre, however, the PCCF is open to all U of S faculty within available instrument and personnel capacity.||Contact|
|Room #||Equipment Description||Model #|
|B46||Biacore: Surface plasmon resonance to measure binding and/or protein-protein interactions||GE T200|
|B46||Laser Scanner Micro Dissection|
|GD10||Histology - Microtome|
|GD40||Microscope - Confocal||Zeiss LSM 700|
|GD45.1||Laser - Mai Tai XF mode-locked Ti:Sapphire laser|
|GD45.1||Laser Scanner - Ultima - X-Y (BX51WI)|
|B128||Centrifuge - Ultra||Beckman Coulter Optima XPN-100|
|2D10||HPLC - with 2996 detector||Waters 2695|
|2D10||PCR System - Digital Drop||QX100|
|2D10.1.1||HPLC - Thermo TSQ Vantage with FAIMS and Agilent 1290 UHPLC - Moved from Agric - not purchased new.||Vantage/FAIMS|
|2D10.1.1||Mass Spectrometer - ABSiex QTRAP 6500 with SelexION ion mobility and Agilent 1290 FPLC.||ABSiex QTRAP 6500|
|2D10.1.1||Mass Spectrometer - Agilent 6460 QQQ||Agilent 6460|
|2D10.1.1||Mass Spectrometer - Agilent 6550 QTOF||Agilent 6550|
|2D10.1.1||Mass Spectrometer - QTRAP||AB Sciex 4000|
|2D40.3.8||Histology - Autostainer System||Dako Autostainer Universal Staining System|
|B253||HPLC system: 2695 separations module, detector system: 2996-photodiode array detector, 2475 multi-wavelength fluorescence detector, 2465 - electrochemical detector.||Waters|
|3D40 Main 10B||FPLC||Biorad NGC Chromatography System Quest 10 Plus|
|3D40 Main 3A||HPLC||Bio-Rad NGC Chromatography System Quest 10 Plus|
|3D40.3||MALS - Multi-Angle Light Scattering (MALS) System||Wyatt|
|3D40.4||Centrifuge - Ultra||Beckman Coulter Optima XPN-100|
|3D40.4.4||Crystal Farm - Automatic Protein Crystallization Robot||Douglas Instruments Oryx 6|
|3D40.4.4||Crystal Farm - Gryphon Liquid Handling System with Wash Pump for Protein Crystallography||Art Robbins Instruments 620-1000-10|
|3D40.4.4||Crystal Farm - Imaging System Bruker Nonius||CF-400-120V|
|3D40.4.5||Plate Reader - Wyatt Technology||DynaPro Plate Reader II|
|3D40.4.5||Spectrophotometer - Circular Dichroism (CD)||Applied Photophysics Chirascan-Plus|
|3D40.4.5||Surface Plasmon Resonance (SPR) System||Reichert Technologies|
|3D40.4.5||Titration Calorimeter - Nano Isothermal||TA Instruments Nano ITC Low Volume|
|3D126.96.36.199||X-Ray Diffractometer - Bruker||D8 Venture|
|4D40||Imaging - Typhoon Phosphor (Radioactive & Fluorescent) Image Analyzer||Typhoon FLA 7000|
|4D40||Microarray System - Gene Chip® - GCS3000||Affymetrix|
|4D40||PCR System - Real-time;||Applied Biosystems StepOne Plus|
|4D40-Imaging Core||Flow Cytometer - CytoFLEX System - 3 lasers; 9 colors||Beckman|
|4D40-Imaging Core||Imaging - Azure or Biorad Imager - UV, Epi white, chemi, RGB fluor, near IR, IR||Azure/VWR or Biorad|
|4D40-Imaging Core||Microscope - Confocal Microscope Zeiss LSM700 system||Zeiss|
|4D40-Imaging Core||Microscope - ImageXpress Micro XLS Widefield High Content Screening System||Molecular Devices|
|4D40-Imaging Core||Microscope - ImageXpress Ultra Confocal High-Content Analysis System||Molecular Devices|
|4D40-Imaging Core||Plate Reader - Microplate SpectraMax M5; Abs and Fluorescence applications||Molecular Devices|
Manager: Cancer Lab (4D40); Translational Cancer Research Cluster Lab (4D10)
Technical Support: Flow Cytometry & Confocal Microscopy
|Vicki Keeler||Manager: Drug Discovery & Development Lab (3D10); Imaging & Developmental Biology Lab (B330); Tissue Culture Core Facility (B307)|
|Heather Neufeld||Manager: Biomedical & Environmental Clusters Lab (2D10); Cardio-Pulmonary Cluster Lab (2D40); Mass Spectrometry & Histology Core Facilities; Wash-Up Technical Support Unit|
Manager: Neurology Labs (Ground Floor); Immunology & Bacteriology Research Cluster Labs (6th Floor)
Technical Support: All Research Clusters
3D Printing: All Research Clusters
|Angela Seto||Manager: Molecular Design Research Cluster Lab (3D40); Health Sciences Supply Centre (HSSC)|
Vision: Together, the health sciences will be leaders in advancing health, locally and globally, through excellence in interprofessional education and practice, interdisciplinary life and health sciences discovery, and committed engagement with stakeholders.
Mission: The health sciences will enhance the capacity for high-quality health care by enabling the education of a new generation of healthcare practitioners with skills in interprofessional healthcare and health promotion, promoting excellence in interdisciplinary health research, and sharing in outreach and community engagement.
To learn more, please access the Health Sciences website.
Office of the Vice-Provost Health (OVPHealth)
The OVPHealth provides a forum to bring the Health Science deans together and provides opportunities to identify shared priorities like finding a way to measure interdisciplinary research.
The mandate of the OVPHealth is strongly focused on enabling Health Science Colleges to work together and harness the breadth of our diverse health ecosystem which includes:
- providing effective stewardship of the Health Sciences Building
- fostering, and promoting interdisciplinary research and interprofessional education
- seeking solutions to systematic barriers
- aligning structures and forging partnerships
- supporting and embracing Indigenization
The work of the OVPH is to cross boundaries; this is not work that is done on the side of our desks – it is our job and includes:
- Building Operations
- Clinical Learning
- Strategic initiatives and special projects
- Planning and hosting truly Interdisciplinary and Interprofessional events informed by a variety of stakeholders