Scott Napper BSc, PhD

Ph.D., Department of Biochemistry, 1999, University of Saskatchewan
B.Sc. Honours, Department of Biochemistry, 1994, University of Saskatchewan

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Dr. Scott Napper holds a joint position at the University of Saskatchewan as a Professor of Biochemistry as well as Senior Scientist at the Vaccine and Infectious Disease Organization- International Vaccine Center (VIDO-InterVac). A protein biochemist by training, his research interests are based in the application of structure-function investigations within the context of infection and immunity. This includes research into the development of vaccines for diseases based in protein misfolding where, by inducing immune responses that are specific to the misfolded species, Dr. Napper hopes to address key obstacles to vaccine development for proteinopathies such as prion diseases and ALS. Dr. Napper is also responsible for the development of peptide arrays that enable high-throughput analysis of intracellular signal transduction activity. This approach has yielded insight and therapeutic targets to a number of important diseases, including a number of infectious diseases of humans and animals as well as cancer.  Outside of the lab Scott has a strong interest in Science Education and works actively with the Secondary Education System to help translate higher level science and mentorship to undergraduate and high school students. Scott is a three-time recipient of the University of Saskatchewan Teaching Excellence Award.

• McDonald M, Trost B, Napper S. Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome. PLoS One. 2018.
• Wood M, Griebel P, Huizenga M, Lockwood S, Hansen C, Potter A, Cashman N, Mapletoft J, Napper S. Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment. Vaccine. 2018.
• Goel RK, Paczkowska M, Reimand J, Napper S, Lukong K. Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Non-receptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS). Mol. Cell. Proteomics. 2018.
• Wu RY, Määttänen P, Napper S, Scruten E, Li B, Koike Y, Johnson-Henry KC, Pierro A, Rossi L, Botts SR, Surette MG, Sherman PM. Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota. Microbiome. 2017.
• Cano P, Gamage LNA, Marciniuk K, Hayes C, Napper S, Hayes S, Griebel PJ. Lambda display phage as a mucosal vaccine delivery vehicle for peptide antigens. Vaccine. 2017.
• Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel PJ, Tikoo S, Napper S. Induction of PrPSc-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease. Prion. 2017.
• Régnier M, Gourbeyre P, Pinton P, Napper S, Laffite J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense A, Guillou H, Loiseau N, Oswald IP. Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine. Mol. Nutr. Food Res. 2017.
• Ogunbolude Y, Dai C, Bagu ET, Goel RK, Miah S, MacAusland-Berg J, Ng CY, Chibbar R, Napper S, Raptis L, Vizeacoumar F, Vizeacoumar F, Bonham K, Lukong KE. FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition. Oncotarget. 2017.
• Baharani A, Trost B, Kusalik A, Napper S. Technological Advances for Interrogating the Human Kinome.. Biochemical Society Transactions. 2017;45:65-77. Epub 2017.
• Wu R, Abdullah M, Maattanen P, Pilar A, Scuten E, Johnson-Henry K, Napper S, O'Brien C, Jones N, Sherman P. Protein kinase Cdelta signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function. Scientific Reports. 2017.
• Régnier M, Gourbeyre P, Pinton P, Napper S, Laffite J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense A, Guillou H, Loiseau N, Oswald IP. Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine. Mol. Nutr. Food Res. 2017.
• Ogunbolude Y, Dai C, Bagu ET, Goel RK, Miah S, MacAusland-Berg J, Ng CY, Chibbar R, Napper S, Raptis L, Vizeacoumar F, Vizeacoumar F, Bonham K, Lukong KE. FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition. Oncotarget. 2017.
• Smith E, Mellor P, Ward A, Kendall S, McDonald M, Vizeacoumar FJ, Vizeacoumar FS, Napper S, Anderson D. Molecular Characterization of breast cancer cell lines through multiple omic approaches. Breast Cancer Research. 2017.
• Chen Y, Arsenault R, Napper S, Griebel P. Methods and Models to Investigate Acute Stress Responses in Cattle. Animals. 2016;5:1268-1295.
• Van Wyk B, Snider M, Scuten E, van Drunen Little-van der Hurk S, Napper S. Induction of functional interferon alpha and gamma responses during acute infection of cattle with non-cytopathic bovine viral diarrhea virus. Veterinary Research. 2016.
• Trost B, Maleki F, Kusalik A, Napper S. DAPPLE 2: a Tool for the Homology-Based Prediction of Post- Translational Modification Sites. Journal of Proteome Research. 2016.
• Facciuolo A, Gonzalez-Cano P, Napper S, Griebel P, Mutharia L. Marked Differences in Mucosal Immune Responses Induced in Ileal versus Jejunal Peyer’s Patches to Mycobacterial avium subsp. Paratuberculosis Secreted Proteins following Targeted Enteric Infection in Young Calves. PLOS One. 2016.
• Chen Y, Stuckey J, Arsenault R, Scruten E, Griebel P, Napper S. Investigation of the Physiological, Behavioral, and Biochemical Responses of Cattle to Restraint Stress. Journal of Animal Science. 2016.
• Trost B, Kusalik A, Napper S. Computational Analysis of the Predicted Evolutionary Conservation of Human Phosphorylation sites. PLOS One. 2016.
• Napper S, Dadgar S, Arsenault R, Trost B, Scruten E, Kusalik A, Shand P. Induction of Tissue- and Stressor- Specific Kinomic Responses in Chickens Exposed to Hot and Cold Stresses.. Poultry Science. 2015.  
• Falcinelli S, Gowen B, Trost B, Napper S, Kusalik A, Johnson R, Safronetz D, Prescott J, Wahl-Jensen V, Jahrling P, Kindrachuk J. Characterization of the Host Response to Pichinde Virus Infection in the Syrian Golden Hamster by Species-Specific Kinome Analysis. Molecular and Cellular Proteomics. 2015.
• Taschuk R, Van der Merwe J, Marciniuk K, Potter A, Cashman N, Griebel P, Napper S. In vitro neutralization of Prions with PrPSc-specific Antibodies.. Prion. 2015.
• Marciniuk K, Trost B, Napper S. EpIC: a rational pipeline for epitope immunogenicity characterization.. Bioinformatics. 2015.
• Taschuk R, Griebel P, Napper S. Carrier Protein Significantly Alters the Magnitude, Duration and Type of Antibody Response to a Peptide Epitope from a Self- Protein.. Journal of Immunology and Vaccinology.
  2015.
• Chen Y, Arsenault R, Napper S, Griebel P. Methods and Models to Investigate Acute Stress Responses in Cattle. Animals. 2016;5:1268-1295.