Team Members

Dr. Nathan Flores-Miranda
Dr. Tony Haddad
Dr. Shah Love
Dr. Parekh Dwip
Dr. Nasim Zamir
Dr. Idris Bare
PhD Candidates
Dr. Natasha Boyes Mostat
Dr. Sabeena Khan
Dr. Udoka Okpalauwaekwe
Pharmacist
Rama Mangipudi
Medical Students
David Kim
Michael Durr
Revathi Nair
Dmitry Neymark
Prapti Patel
Students
Sam Papp
Nathan Braun
Everett Wells
Michael Korol

Grants

Coming Soon.

Research Projects

An industry-sponsored clinical study to evaluate how accurate is the Emergency Care for Heart Attack and Stroke (ECHAS) prehospital mobile app and sensor triage system in identifying patients with stroke, myocardial infarction (MI), or related conditions requiring emergency evaluation. 

Study lead: Dr. Jay Shavadia.

https://clinicaltrials.gov/ct2/show/NCT05230069

The objective of this study is to 1) quantify the risk of an actionable arrhythmia beyond the first 24 hours of presentation, 2) identify patient-level predictors most strongly associated with this risk, and 3) provide a descriptive cost analysis of the current RUH STEMI telemetry pathway.

Study lead: Dr. Haissam Haddad

Improving cardiac care quality in Saskatchewan by applying tailored algorithmic treatment protocols for acute coronary syndromes (ACS): a longitudinal study: This study aims to improve provincial care for patients who present to the Royal University Hospital (RUH) with acute coronary syndrome (ACS), while investigating primarily, the predictors of adverse post-percutaneous coronary intervention (PCI) outcomes in patients with ACS, subcategorised under NSTEMI/UA and STEMI.

Adverse trends and patterns are also examined for covariates such as demographic characteristics, indigenous vs non-indigenous relationships, patient risk factors, diagnostic investigations and therapeutic measures.

It is hoped that outcomes from this study will facilitate the development of patient-centered treatment algorithms for ACS within the province.

Study leads are Dr. Haddad and Dr. Shavadia.

Sub studies include: 

  • Gender Differences in Morbidity and Mortality (Jay, Udoka, Sabeena, Tony, Idris)
  • Short Term Outcomes of Acute Coronary Syndromes by Diabetes Status
  • Cardiogenic shock and cardiac arrest in STEMI (Jay, Love, Dwip, Nathan, Udoka, Sabeena)
  • Clinical characteristics and outcomes of young patients presenting with ST-segment elevation myocardial infarction (Jay, Udoka, Sabeena)
  • Comparison of Demographics and Outcomes of NSTEMI/UA in the Pre- and Peri-COVID19 Pandemic (Jay, Udoka, Michael Durr, Sabeena)
  • Polypharmacy among ACS patients (Jay, Udoka)
  • Depressive symptomatology in ACS patients: correlates and risk factors (Jay, Udoka)
  • Demographics and outcomes of ACS by COVID-19 status (Jay, Udoka)
  • Cardiovascular Outcomes of Acute Coronary Syndromes in Indigenous Compared with Non-Indigenous Patients (Jay, Udoka, Sabeena)
  • Anxiety and Depression in ACS patients with Diabetes Mellitus (Jay, Udoka, Rabia)
  • ACS-related post-PCI clinical outcomes in Saskatchewan (Jay, Udoka)

Optimization of heart failure (HF) therapy in Saskatoon hospitals: This is designed as a retrospective-prospective study to investigate heart failure management among in-patients in cardiac care wards in Saskatoon hospitals, in view to create a standardized algorithm for management of heart failure for professional training and quality improvement.

We believe the outcomes of this study could be expanded to other cardiac centres and hospitals across the province.

Study leads are Dr. Haddad and Dr. Shavadia.

The understanding of how heart muscle weakens (heart failure) following a major heart attack (STEMI) remains unclear but is thought to involve several complexly linked pathways. To improve the understanding of this process, this study aims to evaluate and compare how blood proteins are differently distributed between STEMI patients who do and do not develop heart failure, shock, death and/or a repeat heart attack in follow-up.  

By leveraging the advances in serum proteomics using mass spectroscopy analysis and left ventricular imaging using an echocardiogram, the current study aims to integrate the synergistic evaluations of multi-marker proteins and left ventricular (LV) strain imaging to enhance our understanding of LV repair/healing, and their relationship to clinical outcomes in STEMI patients presenting with and without cardiogenic shock at baseline. 

Principal investigator: Dr. Jay Shavadia

BEta blocker dEprescription Following coronary artery Bypass graft sURGERy: feasibility and safety pilot (BEEFBURGER) Trial (Saskatoon and Regina). 

Study Lead: Dr. Jay Shavadia

NACMI registry is a multi-center database of case reports of patients who present with ST-segment elevation or new left bundle branch block (LBBB) on ECG and are COVID-19 positive or have suspected COVID-19. This study will be beneficial in identifying patterns of myocardial injury, developing a risk model for cardiac complications, understanding short and long-term major adverse cardiac events, and designing clinical trials testing different treatment modalities.

Colchicine and Spironolactone in Patients with MI/SYNEGRY Stent Registry (Clear Synergy OASIS 9) clinical trial (Pan-Canadian). Study Lead: Dr. Jay Shavadia

Publications

  • Muhammadzai H, Okpalauwaekwe U, Shavadia JS, Haddad H. Antemortem Diagnosis of Nonbacterial Thrombotic Endocarditis in A Patient with Previously Resected Pancreatic Adenocarcinoma: A Case Report. European Heart Journal-Case Reports. Accepted May 1, 2020. In Press.
  • Haddad H, Bergeron S, Ignaszewski A, Searles G, Rochdi D, Dhage P, Bastien N. Canadian Real-world Experience of Using Sacubitril/valsartan in Patients with Heart Failure with Reduced Ejection Fraction: Insight from the PARASAIL Study. CJC Open. 2020 Apr 26. Doi: https://doi.org/10.1016/j.cjco.2020.04.007
  • Haddad H, Okpalauwaekwe U, Sharma N, Shavadia JS, Zhai A, Haddad T. Anticoagulation in Cardiac Patients. In: Precision Anticoagulation Medicine 2020 (pp. 77-102). Springer, Cham.
    • Haddad H, Okpalauwaekwe U. Anticoagulation in Patients with Atrial Fibrillation and Artificial Valves: Translating International Guidelines for Clinical Practice. In: Precision Anticoagulation Medicine 2020 (pp. 79-87). Springer, Cham.
    • Shavadia JS, Sharma N, Haddad H. Atrial Fibrillation and Combination Antithrombotic Therapies in Patients Undergoing PCI. In: Precision Anticoagulation Medicine 2020 (pp. 88-93). Springer, Cham.
    • Zhai A, Haddad T. Anticoagulation in Heart Failure and Atrial Fibrillation. In: Precision Anticoagulation Medicine 2020 (pp. 94-97). Springer, Cham.
  • Nafisa Absher, Javeria Muhammadzai, Udoka Okpalauwaekwe, Masud Rana, Abbas Khani-Hanjani, Taras Mycyk, Gregory Dalshaug, Marnie Olson, Haissam Haddad, Jay Shavadia. Contemporary profile and short-term outcomes of patients undergoing coronary artery bypass graft surgery: a single centre experience. University of Saskatchewan CoM Undergraduate Research Showcase [abstract/poster]. October 21, 2020. Saskatoon, SK.
  • Parekh, D, Shavadia JS, Shah L, Flores Miranda N, Shokar, M, Masud R, Okpalauwaekwe U, Haddad H. Cardiogenic shock and cardiac arrest in STEMI: characteristics and outcomes in Northern Saskatchewan. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Shavadia JS, Okpalauwaekwe U, Muhammadzai H, Masud R, Pausjenssen E, Haddad H. Short Term Outcomes of Acute Coronary Syndromes by Diabetes Status: Bridging the Gap with Contemporary Therapies? 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Shavadia JS, Okpalauwaekwe U, Masud R, Pausjenssen E, Haddad H. Acute Coronary Syndromes in Northern Saskatchewan: An Overview of Clinical Characteristics and Outcomes. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Shavadia JS, Okpalauwaekwe U, Masud R, Pausjenssen E, Haddad H. Cardiovascular Profile and Outcomes of Acute Coronary Syndromes in Indigenous Compared with Non-Indigenous Patients: An Observational Analysis from Northern Saskatchewan. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Masud R, Okpalauwaekwe U, Muhammadzai H, Shavadia JS, Haddad H. Regional variations in rehospitalization and mortality risk from cardiovascular disease in Saskatchewan. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Haddad T, Shavadia JS, Okpalauwaekwe U, Masud R, Haddad H. Gender Differences in Morbidity and Mortality of Acute Coronary Syndromes in Northern Saskatchewan. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Zamir N, Shavadia JS, Miranda NF, Coverett K, Parekh D, Shoker M, Haddad H. Actionable arrhythmias in low-risk STEMI patients: the role of continuous ECG monitoring beyond 48 hours of reperfusion. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted. 
  • Shavadia JS, Minhas R, Orvold J, Basran R, Wells C, Devilliers J, Pearce C, Eckstein J, PausJenssen E, Mangipudi R, Rana M, Haddad H. Metformin Continuation versus Interruption Following Coronary Angiography: Contemporary Risk of Lactic Acidosis. A Pilot Single-Center Randomized Control Trial. 2020 Canadian Cardiovascular Congress [abstract]. October 22-25, 2020 at Edmonton Convention Centre, Edmonton, Alberta, Canada. Submitted.

Contact Us

For more information, please contact:

cv.researchgroup@usask.ca

1-306-844-1132