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College of Medicine

Research Area(s)

  • Microbial Genomics
  • Genomic Epidemiology
  • Next-Generation Sequencing
  • Bioinformatics
  • Biofilms
  • Point-of-Care Testing
  • Salmonella
  • SARS-CoV-2
  • Syphilis

About

Keith is an Associate Clinical Scientist with the Saskatchewan Health Authority. His expertise include molecular microbiology and microbial genomics. Keith uses molecular methods, including PCR, next-generation sequencing, and bioinformatics for the detection, typing, and surveillance of microbial pathogens associated with infectious diseases and public health.

Education

Ph.D. in Microbiology and Immunology, University of Saskatchewan

Clinical Interests

  • Molecular Microbiology
  • Microbial Genomics
  • Bioinformatics
  • Point-of-Care Testing
  • SARS-CoV-2
  • Syphilis

Selected Publications

MacKenzie KD, Wang Y, Musicha P, Hansen EG, Palmer MB, Herman DJ, Feasey NA, White AP. Parallel evolution leading to impaired biofilm formation in invasive Salmonella strains. PLoS Genet. 2019 Jun;15(6):e1008233. doi: 10.1371/journal.pgen.1008233. eCollection 2019 Jun. PubMed PMID: 31233504; PubMed Central PMCID: PMC6611641.

MacKenzie KD, Palmer MB, Köster WL, White AP. Examining the Link between Biofilm Formation and the Ability of Pathogenic Salmonella Strains to Colonize Multiple Host Species. Front Vet Sci. 2017;4:138. doi: 10.3389/fvets.2017.00138. eCollection 2017. Review. PubMed PMID: 29159172; PubMed Central PMCID: PMC5581909.

Shivak DJ, MacKenzie KD, Watson NL, Pasternak JA, Jones BD, Wang Y, DeVinney R, Wilson HL, Surette MG, White AP. A Modular, Tn7-Based System for Making Bioluminescent or Fluorescent Salmonella and Escherichia coli Strains. Appl Environ Microbiol. 2016 Aug 15;82(16):4931-43. doi: 10.1128/AEM.01346-16. Print 2016 Aug 15. PubMed PMID: 27260360; PubMed Central PMCID: PMC4968541.

MacKenzie KD, Wang Y, Shivak DJ, Wong CS, Hoffman LJ, Lam S, Kröger C, Cameron AD, Townsend HG, Köster W, White AP. Bistable expression of CsgD in Salmonella enterica serovar Typhimurium connects virulence to persistence. Infect Immun. 2015 Jun;83(6):2312-26. doi: 10.1128/IAI.00137-15. Epub 2015 Mar 30. PubMed PMID: 25824832; PubMed Central PMCID: PMC4432751.