College of Medicine

Research Area(s)

  • Multiple Sclerosis
  • Mobility



  • B Kinesiology, McMaster University
  • MD, McMaster University
  • FRCPC Physical Medicine & Rehabilitation, University of Saskatchewan


Dr. Knox is an Associate professor at the University of Saskatchewan, Department of Physical Medicine and Rehabilitation. Her clinical practice includes neuro- rehabilitation services, with a special interest in multiple sclerosis. She obtained her fellowship training in Physical Medicine and Rehabilitation at the University of Saskatchewan (2006), and her Doctor of Medicine and Kinesiology degrees at McMaster University.  She is a primary investigator with the Cameco MS Neuroscience Research Center at the University of Saskatchewan.  Her clinical research focuses on gait, exercise behavior, long term outcomes and quality of life for people with multiple sclerosis.

Clinical Interests

  • Multiple Sclerosis
  • General Physiatry
  • Spasticity

Selected Publications


  • KB. Knox, Darren Nickel, Sarah J. Donkers, Lorna Paul . (2022). Physiotherapist and participant perspectives from a randomized-controlled trial of physiotherapist-supported online vs. paper-based exercise programs for people with moderate to severe multiple sclerosis. Disability and Rehabilitation. : 1-7.
  • Sarpong-Kumankomah, Sophia, Katherine B. Knox, Michael E. Kelly, Gary Hunter, Bogdan Popescu, Helen Nichol, Karen Kopciuk, Henry Ntanda, and Jürgen Gailer. (2022). Quantification of human plasma metalloproteins in multiple sclerosis, ischemic stroke and healthy controls reveals an association of haptoglobin-hemoglobin complexes with age. PloS One. 17(1): p.e0262160-e0262160.
  • Sessford JD, Locke SR, Cary MA, For a PK, Knox K, Brawley LR. (2021). Effect of group counseling plus tailored exercise on mobility function in multiple sclerosis. International Journal of MS Care. 23(2): 66-72.
  • Knox KB, Saini A, Levin MC. (2020). The Dilemma of When to Stop Disease-Modifying Therapy in Multiple Sclerosis: A Narrative Review and Canadian Regional Reimbursement Policies. International Journal of MS Care. 22(2): 75-85. 
  • Saini A, Bach K, Poliakov I, Knox KB, Levin MC. (2021). Magnetic Resonance Imaging of Spinal Cord Lesions in Patients with Multiple Sclerosis in Saskatchewan, Canada. International Journal of MS Care. 23(2): 47-51. 
  • Donkers SJ, Nickel D, Paul L, Wiegers, SR, Knox KB. (2020). Adherence to physiotherapy-guided webbased exercise for persons living with moderate to severe multiple sclerosis: a randomized-controlled pilot study. International Journal of Multiple Sclerosis Care. 22(5): 208-214. 
  • Al-Sakran L, Marrie RA, Blackburn D, Knox K, Evans C. (2020). Impact of comorbidity on hospitalizations in individuals newly diagnosed with multiple sclerosis: a longitudinal population-based study. Multiple Sclerosis Related Disorders. 40: 1-7.
  • Al-Sakran, Lina H, Ruth Ann Marrie, David F Blackburn, Katherine B Knox, and Charity D Evans. Predictors of Hospitalization in a Canadian MS Population: A Matched Cohort Study. Multiple Sclerosis and Related Disorders 41 (2020): 102028. Web.
  • Al-Sakran LH, Marrie RA, Blackburn DF, Knox KB, Evans CD. Establishing the incidence and prevalence of multiple sclerosis in Saskatchewan. Can J Neuro Sci. 2018; 45(3): 295-303. doi: 10.1017/cjn.2017.301.
  • Knox K, Clay L, Stuart-Kobitz K, Nickel D. Perspectives on walking from people with multiple sclerosis and reactions to video self-observation. Disability & Rehabilitation. [Published online: 22 Oct 2018] doi: 10.1080/09638288.2018.1496154
  • Martin N, Traboulsee AL, Machan L, Klass D, Ellchuk T, Zhao Y, Knox KB, Kopriva D, Lala S, Nickel D, Otani R, Rauscher A, Perera WR, Sadovnick AD, Szkup P, Li D. Prevalence of extra-cranial venous narrowing on Magnetic Resonance Venography is similar in people with MS, their siblings, and unrelated healthy controls: a blinded, case-control study. Canadian Association of Radiologists Journal. 2017 May;68(2):202-209.
  • Hughes KE, Nickel D, Gurney-Dunlop T, Knox KB. Total knee arthroplasty in multiple sclerosis. Arthroplasty Today. 2016;2(3):117-122. doi:
  • Carlson RJ, Doucette JR, Knox K, Nazarali AJ. Pharmacogenomics of interferon-β in multiple sclerosis: What has been accomplished and how can we ensure future progress? Cytokine Growth Factor Reviews. 2015;26(2):249-261.
  • Goodridge D, Rogers M, Klassen L, Jeffery B, Knox K, Rohatinsky N, Linassi G. Access to health and support services: perspectives of people living with a long-term traumatic spinal cord injury in rural and urban areas. Disability and Rehabilitation. 2015;37(16):1401-10. Pubmed PMID: 25332089.
  • Thorpe LU, Knox K, Jalbert R, Lim JHJ, Nickel D, Hader WJ. Predictors of institutionalization for people with multiple sclerosis. Disability and Health Journal 2015;8:271-277.
  • Knox KB, Rohatinsky N, Rogers M, Goodridge D, Linassi G. Access to traumatic spinal cord injury care in Saskatchewan, Canada: A qualitative study on community healthcare provider perspectives. Canadian Journal of Disability Studies. 2014;3(3):83-103. doi:
  • Ploughman M, Beaulieu S, Harris C, Hogan S, Manning O, Alderdice P, Fisk JD, Sadovnick D, O’Connor P, Morrow S, Metz LM, Smyth P, Mayo N, Marrie RA, Knox KB, Stefanelli M, Godwin M. The Canadian Survey of Health, Lifestyle and Aging with Multiple Sclerosis: methodology and initial results. BMJ Open. 2014;4:e005718.