- Airway Inflammation
- Airway Virus infections
- Development of Asthma
About Dr. Darryl Adamko
After completing medical school in 1989-1993, Dr. Darryl J. Adamko continued on to specialty training in Pediatrics at the University of Saskatchewan (1989-1997). He then became a Pediatric Pulmonary Specialist with a strong bench research background after training in a Pediatric Pulmonary Fellowship at The Johns Hopkins University in Baltimore, Maryland (1997-2001). He was an Associate Professor of Pediatrics Pediatric Pulmonary Medicine and an Adjunct Associate Professor of Medicine at the University of Alberta since 2001. He is now at the University of Saskatchewan in a similar position that is focused on clinical, research, and educational aspects of pediatric pulmonary diseases.
Dr. Adamko’s research focus has been within the field of asthma primarily. He has developed expertise in understanding the mechanisms of virus induced asthma attacks. In addition, he has been studying the mechanisms underlying the development of asthma from infancy. This includes in vitro and in vivo models in humans and animals. In the last nine years, he also has been the lead on team grants developing a novel way to diagnose and monitor patients with asthma using nuclear magnetic resonance analysis of urine. This work has great potential to improve the care for patients with respiratory diseases. Based on this research, he is first author on a patent and Director for a company called Respirlyte.
Dr. Adamko is married with two kids (a daughter and a son). He continues to enjoy teaching students in medical school, as well as graduate and postdoctoral students in his lab. He was an AHFMR Clinical Investigator and has had funding through the Sick Kids Foundation, CIHR, ALA, and AllerGen.
- General Pulmonary Medicine
1. Darryl J. Adamko, B.L. Yost, A.D. Fryer, and D.B. Jacoby. Ovalbumin sensitization changes the inflammatory response to subsequent viral infection. Eosinophils mediate airway responsiveness, M2 muscarinic receptor dysfunction, and antiviral effects. 1999, J Exp Med; 190 (10): 1465-78.
2. Darryl J. Adamko, A.D. Fryer, B.S. Bochner and D.B. Jacoby. CD8+ T-Lymphocytes in Viral Hyperreactivity and M2 Muscarinic Receptor Dysfunction. 2003, AJRCCM, Feb 15;167(4):550-6.
3. Darryl J. Adamko, Ying Wu, Gerald Gleich, Paige Lacy and Redwan Moqbel. The Induction of Eosinophil Peroxidase Release: Improved Methods of Measurement and Stimulation. 2004, J Immunological Methods, Vol 291/1-2, 101-108.
4. Francis Davoine, Min Cao, Yingqi Wu, Farnam Ajamian, Ramses Ilarraza, Andy Kokaji, Redwan Moqbel, and Darryl J. Adamko. Virus-induced eosinophil mediator release requires antigen presenting and CD4+ T-cells. J Allergy Clin Immunol. 2008 Jul;122(1):69-77, 77.e1-2. Epub 2008 May 9.
5. Darryl J. Adamko, Yingqi Wu, Farnam Ajamian, Ramses Ilarraza, Redwan Moqbel, and Gerald J. Gleich. The Effect of Cationic Charge on Release of Eosinophil Mediators. 2008, J. Allergy Clin Immunol. 2008 Aug;122(2):383-90, 390.e1-4. Epub 2008 May 2. PMID: 18455220
6. Erik J. Saude, Idongesit P. Obiefuna, Ray L. Somorjai, Farnam Ajamian, Christopher Skappak, Taisir Ahmad, Brion K. Dolenko, Brian D. Sykes, Redwan Moqbel, and Darryl J. Adamko. Metabolomic Biomarkers in an Animal Model of Asthma: Urine Nuclear Magnetic Resonance. Am J Respir Crit Care Med. 2009 Jan 1;179(1):25-34. Epub 2008 Oct 17. PMID: 18931331
7. Erik J. Saude, Christopher Skappak, Kim Cook, Shana Regush, Brian H. Rowe, Redwan Moqbel, Brian D. Sykes, and Darryl J. Adamko. Metabolomic Profiling Pediatric Asthma: the Diagnostic Utility of Urine NMR. J Allergy Clin Immunol. 2011 Mar;127(3):757-64.e1-6. PMID: 21377043
8. Ramses Ilarraza, Yingqi Wu, Francis Davoine, Cory Ebeling, and Darryl J. Adamko. Human dendritic cells promote an antiviral immune response when stimulated by CVT-E002. J Pharm Pharmacol. 2011 May;63(5):670-678. doi: 10.1111/j.2042-7158.2011.01257.x. Epub 2011 Apr 4. PMID: 21492169
9. Cory Ebeling, Yinqi Wu , John R. Gordon, PhD ‡, and Darryl J. Adamko. Compound CVT-E002 significantly reduces allergen induced airway inflammation and airway hyperresponsiveness in vivo. Molecular Nutrition and Food Research, 2011, Dec;55(12):1905-8. doi: 10.1002/mnfr.201100216. Epub 2011 Oct 31.2
10. Darryl J. Adamko, Carina M. Majaesic, Christopher Skappak, and Adrian B. Jones. A pilot-study on the treatment of gastroesophageal reflux-related cough in infants. 2012, In Press, Translational Pediatrics.
11. Ramses Ilarraza, Yingqi Wu, and Darryl J. Adamko. Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro. Int Arch Allergy Immunol 2012;159:422-427 (DOI: 10.1159/000338818).
12. Adamko DJ, Majaesic CM, Skappak C, Jones AB. A pilot trial on the treatment of gastroesophageal reflux-related cough in infants. Zhongguo Dang Dai Er Ke Za Zhi. 2012 May;14(5):321-7. Chinese. PMID: 22613099
13. Davoine F, Sim A, Tang C, Fisher S, Ethier C, Puttagunta L, Wu Y, McGaw WT, Yu D, Cameron L, Adamko DJ, Moqbel R. Eosinophils in human oral squamous carcinoma; role of prostaglandin D2. J Inflamm (Lond). 2013 Jan 31;10(1):4. PMID: 23369060
14. Ramses Ilarraza, PhD, Yingqi Wu, Christopher D. Skappak, Farnam Ajamian, MD, David Proud, PhD4 and Darryl J. Adamko, MD, FRCPC. Rhinovirus Has The Unique Ability To Directly Activate Human T Cells In Vitro. J Allergy Clin Immunol, 2013, Feb;131(2):395-404. (doi: 10.1016/j.jaci.2012.11.041). PMID: 23374267