- Mycobacterial virulence factors, TB host-pathogen interactions, TB vaccine and drug development, TB animal modeling, TB aerobiology
Dr. Chen received a BSc (Hons) in marine biology and biochemistry from Dalhousie University, and a PhD in molecular genetics and microbiology from the University of Toronto. He was a Canadian Lung Association and the Canadian Institutes of Health Research post-doctoral fellow at the École Polytechnique Fédérale de Lausanne, Global Health Institute in Switzerland.
His research is presently focused on the following areas:
1. Understanding the role of the multi-component type-7 secretion system ESX-1 in TB host-pathogen interactions (NSERC-funded)
2. Developing the next generation of live BCG vaccines for TB (National Sanitarium Association & US DoD-funded)
3. Developing a porcine model of TB infection and transmission (Saskatchewan Health Research Foundation & National Sanitarium Association-funded)
4. Harnessing BCG-mediated trained immunity as an alternative to broad-spectrum antibiotics and antivirals for humans and livestock (Alberta Forestry & Agriculture-funded)