College of Medicine

Research Area(s)

  • The flagellum secretion system in Helicobacter pylori, and chromatin modifying systems in higher eukaryotes.

About

Ph.D., University of Alberta, 1994, Structural Biology
B.Sc. Honours, Dalhousie University, 1986, Chemistry


Biography

Dr. Moore was born and raised in Halifax, Nova Scotia. He attended Queen Elizabeth High School and studied Chemistry at Dalhousie University, earning his BSc with Honors in 1986. From 1986 to 1987, he worked on the identification of marine natural products at the National Research Council's Atlantic Research Laboratory under the supervision of Dr. Jeffrey L. C. Wright. Dr Moore completed PhD studies in Biochemistry at the University of Alberta in 1994, where he studied protein crystallography under the supervision of Michael N. G. James. In 1994, Dr Moore took up a Post Doctoral Fellowship with Edward N. Baker at Massey University in New Zealand, where he worked on determining the structures of various proteins including lactoferrin, transferrin and aldehyde dehydrogenase. Dr Moore joined the faculty of Massey University in 1998 as a Lecturer and remained there for four years. Since 2002, Dr Moore has been an Associate Professor in the Dept. of Biochemistry at the University of Saskatchewan. His current research interests include the flagellum secretion system in Helicobacter pylori, and chromatin modifying systems in higher eukaryotes.

** Dr. Moore doesn't endorse smoking - however, he does infrequently partake in the occasional black licorice cigar!

Recent Publications

  • Li, J., Jia, Y., Lin, A., Hanna, M., Chelico, L., Xiao, W., and Moore S. A. (2019). Structure of Ddi2, a highly inducible detoxifying metalloenzyme from S. cerevisiae J. Biol. Chem. 294, 10674-10685
  • Marshall, J. D. S., Mellor, P., Ruan, X., Whitecross, D. E., Moore, S. A and Anderson, D. H. (2018). Insight into the PTEN – p85α interaction and lipid binding properties of the p85α BH domain Oncotarget 9, 36975-36992.
  • Mellor P, Marshall JDS, Ruan X, Whitecross DE, Ross RL, Knowles MA, Moore SA, Anderson DH. Patient-derived mutations within the N- terminal domains of p85alpha impact PTEN or Rab5 binding and regulation. Scientific Reports. 2018 May 8;8:7108. Epub 2018 May 8 DOI:10.1038/s41598-018-25487-5.
  • Li J. , Biss, M., Fu, Y., Xu, X., Moore S. A. and Xiao, W. Two Duplicated Genes DDI2 and DDI3 in Budding Yeast Encode a Cyanamide Hydratase and are Induced by Cyanamide. Journal of Biological Chemistry. 2015 May;290:12664-12675. Epub 2015 Apr. PMID: 25847245.