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College of Medicine

Research Area(s)

  • Molecular regulation of embryonic cartilage and differentiation

About

Research focuses on cell-matrix interactions and signal transduction processes regulating cartilage differentiation in the embryonic limb and craniofacial structures. Biochemical and molecular techniques are employed to identify intracellular and extracellular factors controlling cartilage-specific gene expression.

Selected Publications

  • Little CJ, Kulyk WM, Chen X.  The Effect of Chondroitin Sulphate and Hyaluronic Acid on Chondrocytes Cultured within a Fibrin-Alginate Hydrogel.  J Funct Biomater. 2014 Sep 18;5(3):197-210.
  • Izadifar Z, Chen X, Kulyk W.  Strategic design and fabrication of engineered scaffolds for articular cartilage repair.  J Funct Biomater. 2012 Nov 14;3(4):799-838.
  • Xu Y, Wei K, Kulyk W, Gong SG.  FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis.  J Cell Biochem. 2011 Nov;112(11):3440-8.
  • Smith TM, Wang X, Zhang W, Kulyk W, Nazarali AJ.  Hoxa2 plays a direct role in murine palate development.  Dev Dyn. 2009 Sep;238(9):2364-73.
  • Bobick BE, Kulyk WM.  Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling. Birth Defects Res C Embryo Today. 2008 Jun;84(2):131-54. Review.
  • Wiens R, Rak M, Cox N, Abraham S, Juurlink BH, Kulyk WM, Gough KM.  Synchrotron FTIR microspectroscopic analysis of the effects of anti-inflammatory therapeutics on wound healing in laminectomized rats. Anal Bioanal Chem. 2007 Mar;387(5):1679-89. Epub 2007 Jan 27.
  • Bobick BE, Thornhill TM, Kulyk WM.  Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation.
  • J Cell Physiol. 2007 Apr;211(1):233-43. Bobick, B.E. and W. M. Kulyk. (2006). MEK-ERK Signaling Plays Diverse Roles in the Regulation of Facial Chondrogenesis. Experimental Cell Research, April 15, 2006; 312(7):1079-1092. (journal Impact Factor = 4.15)
  • Bobick, B.E. and W. M. Kulyk. (2004). The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme. Journal of Biological Chemistry,  Feb 6, 2004; 279(6):4588-95.
  • J.F. Wang, M.E. Olson, R.J. Winkfein , W.M. Kulyk, J.B. Wright, D.A. Hart, 2002. Molecular and cell biology of porcine HSP47 during wound healing: complete cDNA sequence and regulation of gene expression. Wound Repair and Regeneration, July 2002; 10(4):230-40.
  • D.A. Hart, C. Reno, M.P. H. LeGraverand, L. Hoffman, and W.M. Kulyk, 2000. Expression of heat shock protein 47 (Hsp47) mRNA levels in rabbit connective tissues during the response to injury and in pregnancy. Biochemistry and Cell Biology 78(4):511-518.
  • J.F. Wang, M.E. Olson, C.R. Reno, W.M. Kulyk, B.J. Wright, and D.A. Hart, 2000. Molecular and cell biology of skin wound healing in a pig model. Connective Tissue Research 41(3):195-211.
  • W.M. Kulyk, J. L. Franklin, and L.M. Hoffman, 2000. Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme.Experimental Cell Research 255: 327-332.
  • L.M. Hoffman and W.M. Kulyk, 1999. Alcohol promotes in vitro chondrogenesis in embryonic facial mesenchyme. International Journal of Developmental Biology, 43: 167-174.
  • W.M. Kulyk and L.M. Hoffman, 1996. Ethanol exposure stimulates cartilage differentiation by embryonic limb mesenchyme cells. Experimental Cell Research223: 290-300.
  • D.S. Pearson, W.M. Kulyk, G.M. Kelly, and P.H. Krone, 1996. Cloning and characterization of a cDNA encoding the collagen-binding stress protein hsp47 in zebrafish. DNA and Cell Biology, 15(3): 263-272.