Kailash Prasad - College of Medicine - Medicine

Research Area(s)

Oxyradicals in cardiovascular diseases and diabetes
Flaxseed and its components in cardiovascular disease and diabetes

About

F.I.A.C.S. (Fellow of the International Academy of Sciences)
F.R.C.P.C. (Fellow of the Royal college of Physicians Canada)
F.A.C.C. (Fellow of American College of Cardiology)
Ph.D., Pharmacology, University of Alberta, 1967, College of Medicine
M.D., University of Delhi, India, 1961, Lady Hardinge Medical College
M.B.B.S. (Honours), Bihar University, India, 1957, Darbhanga Medical College
B.Sc. (Distinction), Patna University, India, 1952, Science College, Patna

Teaching Interests

Cardiovascular Physiology (Graduate classes only)

Significant and Active Research Funding

Heart and Stroke Foundation of Saskatchewan and CIHR- Oxyradicals in cardiovascular diseases and diabetes; Flaxseed and the components in cardiovascular diseases.

Selected Publications

Books:

Textbook of Angiology. Editors, J.B. Chang, K. Prasad, B.E. Sumpio, E. Olsen. Springer Verlag, New York Inc., 2000; 1394 pages.

Book Chapters:

Lee, P., Qureshi M., Prasad K. Cardiovascular dysfunction and cellular injury – Role of antioxidants. In: Antioxidants and cardiovascular Disease. eds. R. Nath, M. Khullar and P.K. Singal. Narosa Publishing House, New Delhi, India, 2004, pp. 143-149.

Prasad K. Flaxseed in the prevention of cardiovascular diseases. In: Flax. The genus linum. eds. Muir A.D. and Westcott M.D. Taylor & Francis Inc., New York, U.S.A. 2003: pp. 204-213.

Prasad K. Flaxseed and prevention of hypercholesterolemic atherosclerosis. In: Flaxseed in Human Nutrition, 2nd edition. eds. Cunnane S. and Thompson L. AOCS Press. Champaign, IL, U.S.A., 2003: pp 260-273.

Prasad K. Flaxseed components in the prevention of experimental diabetes. In: Flaxseed in Human Nutrition, 2nd edition. eds. Cunnane S. and Thompson L. AOCS Press. Champaign, IL, U.S.A., 2003: pp 274-287.

Lee P. and Prasad K. Oxyradicals and hypercholesterolemic atherosclerosis. In: Atherosclerosis, Hypertension and Diabetes. eds. Pierce G.N., Nagano M., Zahradka P. and Dhalla N.S Kluwer Academic Publishers, Boston, U.S.A., 2003: pp 63-69.

Prasad K. Antioxidants and Diabetes. Review of the book “Antioxidants in Diabetes”. Review of the book “Antioxidants in Diabetes Managements”. ed. by L. Packer, P. Rosen, H.J. Tritschler, B.L. King and A. Azzi. Trends in Endocrinology and Metabolism, 12:179-180, 2001.

Lee P. and Prasad K. Antioxidants in the prevention of hypercholesterolemic atherosclerosis. In: “Pharmacology and Therapeutics in the New Millennium”. ed. by S.K. Gupta. Narosa Publishing House, New Delhi, 2001: pp 272-276.

Prasad, K. Structure and function of various vascular beds. In: Textbook of Angiology. eds. J.B. Chang, K. Prasad, B.E. Sumpio and E. Olsen. Springer-Verlag, New York Inc., 2000; pp. 3-10.

Prasad, K. Peripheral circulation and its control mechanism. In: Textbook of Angiology. eds. J.B. Chang, K. Prasad, B.E. Sumpio and E. Olsen. Springer-Verlag, New York Inc., 2000; pp. 39-45.

Prasad, K. Blood pressure and its control mechanism. In: Textbook of Angiology. eds. J.B. Chang, K. Prasad, B.E. Sumpio and E. Olsen. Springer-Verlag, New York Inc., 2000; pp. 46-54.

Prasad, K. Oxygen free radicals and peripheral vascular disease. In: Textbook of Angiology. eds. J.B. Chang, K. Prasad, B.E. Sumpio and E. Olsen. Springer-Verlag, New York Inc., 2000; pp. 427-438.

Prasad, K. Pathophysiology of atherosclerosis. In: Textbook of Angiology. eds. J.B. Chang, K. Prasad, B.E. Sumpio and E. Olsen. Springer-Verlag, New York Inc., 2000; pp. 85-105.

Prasad, K., Kungle, J., Raney, B., Mantha, S.V. and Laxdal, V.A. Evaluation of antioxidant activity of allicin in garlic. In: Free Radicals and antioxidants. Ed. Singh, P.P. et al., Chaudhary offset PVT. Ltd; Udaipur, India. 1999; pp. 84 - 881.

Papers in refereed journals:

PUBLISHED (FULL LENGTH, REFEREED JOURNALS):

Prasad, K. Hypocholesterolemic and antiatheroslcerotic effect of flax lignam complex isolated from flaxseed. Atheroschlerosis 179: 269 - 275, 2005.

Prasd, K. Oxyradicals as a mechanism of angiotensin - induced hepertension. Int J. Angiol. 13: 59 - 66, 2004.

Prasad, K. Antihypertensive activity of secoisolariciresinol diglucoside (DSG) isolated from flaxseed: Role of guanylate cyclase. Intl. J. Angiol., 13:7-14, 2004.

Prasad, K. C-reactive protein increases the generation of oxygen radicals by neutrophils. J. Cardiovasc. Pharmacol. Therapeut. 9:203 - 209, 2004.

Qureshi, M., Khandwala, H., ul-Haq, I. and Prasad, K. Elevated levels of plasma homocysteine in hypertensive patients with diabetes mellitus. J. Cardiovasc. Pharmacol. Therapeut. 8: 261-266, 2003.

Lee, P. and Prasad, K. Effects of flaxseed oil on serum lipids and atherosclerosis in hypercholesterolemic rabbits. J. Cardiovasc. Pharmacol. Therapeut. 8: 227-235, 2003.

Lee, P. and Prasad, K. Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by cyclooxygenase inhibitors. Intl. J. Angiol. 12:13-23, 2003.

Prasad, K. C-reactive protein and cardiovascular diseases. Intl. J. Angiol. 12:1-12, 2003.

Prasad, K. and Lee, P. Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by aspirin. J. Cardiovasc. Pharmacol. Therapeut. 8:61-69. 2003.

Prasad, K. and Lee P. Role of oxyradicals in the pathophysiology of hemorrhagic shock. Intl. J. Angiol. 11:113-128, 2002.

Prasad, K. and Gupta, J.B. Relaxant effect of oxygen free radicals on rabbit tracheal smooth muscle. Pulmonary Pharmacol. Therapeut. 15:375-384, 2002.

Lee, P. and Prasad, K. Hyperhomocysteinemia and venous thrombosis. Intl. J. Lower extremity and wounds 1:4-12, 2002.

Pattanaik, U. and Prasad, K. 2001. Reactive oxygen species and endotoxic shock: Effect of dimethylthiourea. J. Cardiovasc. Pharmacol. Therap. 6:273-285, 2001.

Prasad, K. Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat. J. Lab. Clin. Med. 138:32-39, 2001.

Prasad, K. Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. Internatl. J. Angiol. 9:220-225, 2000.

Prasad, K. Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: Effect of secoisolariciresinol diglucoside (SDG) isolated from flaxseed. Mol. Cell. Biochem. 209:89-96, 2000.

Prasad, K, Mantha, S.V., Muir, A.D. and Westcott, N.D. Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism. Mol. Cell. Biochem. 206:141-150, 2000.

Rajakumar, R.J., Prasad, K., Mantha, S.V., Khouri, M. and Raney, B. Protection of coronary angioplasty-induced oxidative stress by isovue used during angioplasty. Canad. J. Cardiol. 15:989-998, 1999.

Prasad, K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99:1355-1362, 1999.

Prasad, K. Homocysteine, a risk factor for cardiovascular disease. Internatl. J. Angiology 8:76-86, 1998.

Pattanaik, U. and Prasad, K. Oxygen free radicals and endotoxic shock: Effect of flaxseed. J. Cardiovas. Pharmacol. Therapeut. 3:305-318, 1998.

Prasad, K., Mantha, S.V., Muir, A.D. and Westcott, N.D. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Atherosclerosis 136:367-375, 1998.

Prasad, K., Mantha, S.V., Kalra, J., Lee, P. Prevention of hypercholesterolemic atherosclerosis by garlic, an antioxidant. J. Cardiovasc. Pharmacol. Therapeutics 2:309-320, 1997.

Prasad, K. Dietary flaxseed in the prevention of hypercholesterolemic atherosclerosis. Atherosclerosis 132:69-75, 1997.

Prasad, K. Hydroxyl radical scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flaxseed. Mol. Cell. Biochem., 168:116-123, 1997.

Bharadwaj, L.A. and Prasad, K. Mechanism of hydroxyl radical-induced modulation of vascular tone. Fred Radical Biol. Med., 22:381-390, 1997.

Prasad, K. and Bharadwaj, L.A. Hydroxyl radical - a mediator of acetylcholine-induced vascular relaxation. J. Mol. Cell. Cardiology, 28:2033-2041, 1996.

Prasad, K., Chan, W.P. and Bharadwaj, B. Superoxide dismutase and catalase in protection of cardiopulmonary bypass-induced cardiac dysfunction and cellular injury. Canad. J. Cardiol., 12:1083-1091, 1996.

Kakkar, R., Mantha, S.V., Kalra, J. and Prasad, K. Time course study of oxidative stress in aorta and heart of diabetic rat. Clin. Sci., 91:441-448, 1996.

Pattanaik, U. and Prasad, K. Endotoxemia and oxidative stress. Ann. N.Y. Acad. Sci. 793:506-510, 1996.

Prasad, K., Gupta, J.B., Kalra, J., Lee, P., Mantha, S.V. and Bharadwaj, B. Oxidative stress as a mechanism of cardiac failure in chronic volume overload in canine model. J. Mol. Cell. Cardiol. 28:375-385, 1996.

Kapoor, R. and Prasad, K. Role of polymorphonuclear leukocytes in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion. Free Radical Biology and Medicine 21:609-618, 1996.

Prasad, K., Gupta, J.B., Kalra, J., Lee, P., Mantha, S.V. and Bharadwaj, B. Oxidative stress as a mechanism of cardiac failure in chronic volume overload in canine model. J. Mol. Cell. Cardiol. 28:375-385, 1996.

Prasad, K., Debnath, D., Kalra, J. and Prasad, M. Protective effect of methionine in the ischemia-reperfusion cardiac injury in canine model. Intl. J. Angiology 5:93-101, 1996.

Kapoor, R. and Prasad, K. Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: Effect of SOD and catalase. Circ. Shock, 43:79-94, 1994.

Prasad, K. and Laxdal, V.A. Hydroxyl radical-scavenging property of indomethacin. Mol. Cell. Biochem. 136:139-144, 1994.

Prasad, K., Debnath, D., Kalra, J. and Lee, P. Effects of dimethylthiourea on cardiac function and oxyradical status in ischemia/reperfusion injury. Ann. N.Y. Acad. Sci. 723:375-379, 1994.