Picture of Dr. Thomas Fisher (on leave in 2022)

Dr. Thomas Fisher (on leave in 2022) MSc, PhD, BSP Department Head, Anatomy, Physiology and Pharmacology

Address
GA20.16 Health Sciences

Research Area(s)

  • Osmotic regulation of ion channels and vasopressin secretion
  • Ca2+ channel targeting and function in neuroendocrine secretion
  • Mechanisms and significance of gliotransmitter secretion

About

Post-doctoral Research

Neuroscience Research Group, Montreal General Hospital/McGill University, Montreal.
Department of Physiology and Biophysics, The Mayo Clinic, Rochester, MN, USA

Present Research Funding

  • Ca2+ channel targeting in neuroendocrine cells, Natural Sciences and Engineering Research Council of Canada (2009-2014)
  • Structural and functional adaptation of supraoptic neurons to sustained hyperosmolality, Canadian Institutes of Health Research Regional Partnership Program, including matching funds from the Saskatchewan Health Research Foundation (2009-2011)
  • An osmosensitive K+ current that regulates vasopressin release, Heart and Stroke Foundation of Canada (2008-2011).
  • Noradrenergic activation of glial release of ATP and its role in regulation of plasticity at hypothalamic glutamatergic synapses, Canadian Institutes of Health Research (2005-2010; co-investigator with J.S. Bains, University of Calgary)

People In The Lab

Current Graduate Student

Vimal Bansal - Expected Completion 2016

Technician

Xuan Vo "Ca2+ channel subunit composition in neuronal somata and terminals. Noradrenaline-evoked release of ATP from glial cells"

Former Graduate Students

Swarupa Chakraborty
Daoyi Wang Completed Feb 2011 "Ca2+ channel trafficking in neuroendocrine cells"
Naima Mumtaz Completed Jan 2011 "Acute and chronic adaptation of supraoptic neurons to changes in osmolality"
Wenbo Zhang PhD  Completed 2009 "Characterization of a novel osmosensitive K+ current in supraoptic neurons"
Xiaoyu Xu  MSc Completed 2006 "CASK and Mint1 in Ca2+ channel clustering and function in chromaffin cells"
Blanc Star MSc Completed 2005 "Dehydration increases the density of L-type Ca2+ channels in supraoptic neurons"
Xiaohong Liu MSc Completed 2004 "An osmosensitive and voltage sensitive cation current in supraoptic neurons"

Former Post-Doctoral Fellow

Kosala Rajapaksha 2004-2006 "Alternative splicing of Ca2+ channel mRNA. Noradrenaline-evoked release of ATP from glial cells"

Recent Summer Students

Peter Rye* 2009 Mechanisms of osmotically-induced MNC hypertrophy.
Petra Dolman** 2008 Regulation of VP secretion during chronic dehydration.
Catherine Lacny 2008 Mechanisms underlying glial regulation of VP secretion.
Brent Wilkinson 2007 Osmotically-induced structural reorganization in the SON.
Jeff Wilkinson** 2007 Mechanisms underlying glial modulation of VP secretion.
Jeff Wilkinson* 2006 Mechanisms of NA-induced ATP release from glia.
Lauren Beliveau* 2005 Study of secretion from MNCs and glia using FM1-43.

* Recipient of a NSERC Summer Research Award

** Recipient of a Heart & Stroke Foundation Summer Research Award

Honours and Awards for Lab Members

  • Congratulations to Daoyi for having an image chosen for the cover of the Journal of Neuroendocrinology, October 2009!
  • Congratulations to Daoyi on being chosen to represent the University of Saskatchewan at the CIHR Student Health Research Forum 2009!
  • Congratulations to Wenbo on receiving a CIHR Canada Graduate Scholarship Doctoral Award, 2007-09!

APPLICATIONS FOR GRADUATE STUDENT AND POST-DOCTORAL POSITIONS WELCOME!

Selected Publications

Wang, D, Yan, B, Rajapaksha, WRAKJS, and Fisher, TE (2009) Expression of voltage gated Ca2+ channels in glial cells of the rat neurohypophysis. Journal of Neuroendocrinology, in press.

Zhang, W, Wang, D, Liu, X-H, Rajapaksha, WRAKJS, and Fisher, TE (2009) An osmosensitive voltage gated K+current in rat supraoptic neurons. European Journal of Neuroscience, 29, 2335-2346.

Wang, D, Rajapaksha, WRAKJS, Davies, JN, Chen, L,  Zamponi, GW, and Fisher, TE (2008) Novel splice variants of rat CaV2.1 that lack much of the synaptic protein interaction site are expressed in neuroendocrine cells. Journal of Biological Chemistry, 283, 15997-16003.

Zhang, W, Star, B, Rajapaksha, WRAKJS, and Fisher, TE (2007) Dehydration increases L-type Ca2+ current in rat supraoptic neurons. Journal of Physiology, 580, 181-193.

Liu, XH, Zhang, W, and Fisher, TE (2005) A novel osmosensitive voltage gated cation current in rat supraoptic neurones. Journal of Physiology, 568, 61-68.

Gordon, GRJ, Baimoukhametova, DV, Hewitt, SA, Rajapaksha, WRAKJS, Fisher, TE, and Bains, JS (2005) Noradrenaline triggers release of glial ATP to increase postsynaptic efficacy. Nature Neuroscience, 8, 1078-1086.

Fisher, TE, and Bourque, C. W. (2001) The function of Ca2+ channel subtypes in exocytotic secretion: new perspectives from synaptic and non-synaptic release Progress in Biophysics and Molecular Biology, 77, 269-303.

Fisher, TE, Marszalek, PE, and Fernandez, JM (2000) Stretching single protein and sugar molecules into novel conformations using the atomic force microscope Nature Structural Biology, 7,719-724.

Fisher, TE, Carrion-Vazquez, M, Oberhauser, AF, Li, H., Marszalek, PE, and Fernandez, JM (2000) Single molecule force spectroscopy of modular proteins in the nervous system. Neuron, 27, 435-446.

Fisher, TE, Carrion-Vazquez, M, and Fernandez, JM (2000) Ca2+ channel immunoreactivity on intracellular membranes in neuroendocrine axon terminals. FEBS Letters, 482, 131-138.

Fisher, TE, and Fernandez, JM (1999) Pulsed-laser imaging of Ca2+ influx in a neuroendocrine terminal. Journal of Neuroscience, 19, 7450-7457.

Wilson, GF, Richardson, FC, Fisher, TE, Olivera, BM, and Kaczmarek, LK (1996) Identification and characterization of a Ca2+-activated nonspecific cation channel and current underlying prolonged repetitive firing in Aplysia neurons.Journal of Neuroscience, 16, 3661-3671.

Fisher, TE and Bourque, CW (1996) Calcium channel subtypes in the somata and axon terminals of the magnocellular neurosecretory cells of the rat supraoptic nucleus. Trends in Neurosciences, 19, 440-4.

Fisher, TE and Bourque, CW (1995) Distinct w‑agatoxin‑sensitive calcium currents in the somata and axon terminals of a mammalian central neuron. Journal of Physiology 489.2, 383-388.

Fisher, TE and Bourque, CW (1995) Expression of voltage gated calcium channels in the magnocellular neurosecretory cells of the rat hypothalamus. Journal of Physiology 486.3, 571-580.