Dr. Heather Szabo-Rogers PhD

Please contact Heather to discuss the possibility of studying craniofacial development at the MSc, PhD and Post-doc levels.

BSc   (2000)   University of Alberta
Ph.D. (2007)   University of British Columbia
Post Doc         King’s College London

 

Craniofacial Development: 

Congenital craniofacial anomalies are the most common birth defects affecting newborn babies. While present at birth, congenital craniofacial anomalies arise very early in development. Our face develops from separate prominences that must meet each other in the right place and at the right time for typical development to occur. Congenital craniofacial anomalies arise when these processes are disrupted. To begin to understand typical and atypical craniofacial development the lab has three different research focuses. 1) Determining the molecular etiology of Robinow Syndrome, including how Wnt/PCP signaling controls the growth and maturation of craniofacial chondrocytes. 2) The genetic and morphological processes that contribute to the development of orofacial clefts. 3) Control of differentiation and patterning of craniofacial osteoblasts.

Selected Publications: 

MyNCBI link 

• Wan Y, Szabo-Rogers HL. Chondrocyte polarity during endochondral ossification requires protein-protein interactions between Prickle1 and Dishevelled2/3. J Bone Miner Res. 2021. Epub 2021/08/24. doi: 10.1002/jbmr.4428. PubMed PMID: 34423861.
• Liu D, Ban HJ, El Sergani AM, Lee MK, Hecht JT, Wehby GL, Moreno LM, Feingold E, Marazita ML, Cha S, Szabo-Rogers HL, Weinberg SM, Shaffer JR. PRICKLE1 x FOCAD Interaction Revealed by Genome-Wide vQTL Analysis of Human Facial Traits. Front Genet. 2021;12:674642. Epub 2021/08/27. doi: 10.3389/fgene.2021.674642. PubMed PMID: 34434215; PMCID: PMC8381734.
• Lantz, B; White, C; Liu, Y; Wan, Y; Gabriel, G; Lo, CWY; and Szabo-Rogers, HL. Finding Unicorn, a new model for midfacial clefting – the Unicorn mouse line. Genes (Basel). 2020 Jan 11;11(1). doi: 10.3390/genes11010083. PubMed PMID: 31940751; PubMed Central PMCID: PMC7016607.
• Wan, Y; White, C; Robert, N; Rogers, MB; Szabo-Rogers HL. Localization of Tfap2b, Casq2, Penk, Zic1, and Zic3 expression in the developing retina, muscle and sclera of the embryonic mouse eye. Journal of Histochemistry and Cytochemistry. 2019: Oct 22;:22155419885112. doi: 10.1369/0022155419885112. PubMed PMID: 31638440.
• Cho, KY; Kelley, BP; Monier D; Lee B; Szabo-Rogers HL; Napierala, D;. Trps1 regulates Development of craniofacial skeleton and is required for the initiation of palatal shelves fusion. Front Physiol. 2019 10:513
• Wan, Y; Lantz, B; Cusack, BJ; Szabo-Rogers HL;. Prickle1 regulates differentiation of frontal bone osteoblasts. Rep. 2018;8(1)18021.
• Wan Y; Rogers MB; Szabo-Rogers HL;. A six-gene expression toolbox for the glands, epithelium, and chondrocytes in the mouse nasal cavity. Gene expression patterns: GEP. 2017; 27:46-55.
• Hampl, M; Cela, P; Szabo-Rogers, HL; Kunova Bosakova, M; Dosedelova; Krejci, P; Buchtova, M. Role of primary cilia in odontogenesis. Journal of Dental Research, 2017 Jun 1:22034517713688. doi: 10.1177/0022034517713688.2017.
• Cusack BJ, Parsons TE, Weinberg SM, Vieira AR, Szabo-Rogers HL: Growth factor signaling alters the morphology of the zebrafish ethmoid plate. Journal of anatomy 2017, 230(5):701-709