Picture of Dr. David Cooper

Dr. David Cooper BSc, MSc, PhD Faculty, Anatomy & Cell Biology

Research Areas

  • Bone aging, adaptation and disease 3D Imaging Synchrotron Science

About Dr. David Cooper


PDF: University of British Columbia
PhD: University of Calgary
MSc: University of Saskatchewan
BSc: University of Saskatchewan

Associate Professor & Tier II Canada Research Chair

Selected Publications

  • Lieverse AR, Pratt IV, Schulting RJ, Cooper DML, Bazaliiskii VI, Weber AW. 2014. Point taken: An unusual case of incisor agenesis and mandibular trauma in early Bronze Age Siberia. International Journal of Paleopathology. In Press
  • Muhammad T.R., M. Prusinkiewicz, D.M.L. Cooper, G. Belev, M.A. Webb, J.C. Boughner, "Imaging earliest tooth development in 3D using a silver-based tissue contrast agent", Anatomical Record 2013, In Press.
  • Varun P. Gopi, P. Palanisamy, Khan A. Wahid, Paul Babyn, David Cooper, "Micro-CT Image Reconstruction Based on Alternating Direction Augmented Lagrangian method and Total Variation", Computerized Medical Imaging and Graphics, 2013 Epub ahead of print.
  • Yasmin Carter*, C. David L. Thomas, John G. Clement and David M.L. Cooper, "Femoral Osteocyte Lacunar Density, Volume and Morphology in Women Across the Lifespan", Journal of Structural Biology, 2013  183(3), 519-26,
  • Duckham, RL Baxter-Jones ADG Johnston JD Vatanparast, H Cooper D and Kontulainen S, "Does physical activity in adolescence have site and sex specific benefits on young adult bone size, content and estimated strength?", Journal of Bone and Mineral Research,2013, Epub ahead of print.
  • Stefan A. Jackowski, Saija A. Kontulainen, David M.L. Cooper, Joel L. Lanovaz, Thomas J. Beck, and Adam D.G. Baxter Jones1, "Adolescent physical activity and bone strength at the proximal femur in adulthood", Medicine & Science in Sports & Exercise, 2013, Epub ahead of print.
  • Wilson-Gerwing T, Pratt I*, Cooper DML, Silver T, Rosenberg A., "Age-related Differences in Collagen induced Arthritis: Clinical and Imaging Correlations",Comparative Medicine. In Press
  • N. Zhu, D. Cooper, H. Niu, and X.B. Chen, "A Study on the in vitro Degradation of Poly-L-Lactide/Chitosan-Microspheres Scaffolds", Frontiers of Materials Science, 2013 7(1), 76-82.
  • Zhu Z, Wahid K, Babyn P, Cooper D, Pratt I*, Carter Y*., "Improved Compressed Sensing-Based Algorithm for Sparse-View CT Image Reconstruction", Computational and Mathematical Methods in Medicine, 2013 15.
  • Varney T, Swanston T*, Coulthard I, Cooper DML, George G, Pickering I, Murphy R., "A Preliminary Investigation of Lead Poisoning in a Napoleonic Era Naval Cemetery in Antigua", Caribbean Connections, 2013  III(I),
  • Carter, Y. Thomas , C.D.L. Clement, J.G. Peele, A. Hannah, K. and D.M.L. Cooper. Variation in osteocyte lacunar morphology and density inthe human femur - a synchrotron radiation micro-CT study. Bone. 2012 Sep 17;52(1):126-132.
  • Britz, H.M. Carter, Y. Jokihaara, J. Leppänen, O.V. Järvinen, T. Beleve, G. and D.M.L. Cooper. Prolonged unloading in growing ratsreduces cortical osteocyte lacunar density and volume in the distal tibia. Bone.
  • Cooper D.M.L., Chapman LD, Carter Y, Wu Y, Panahifar A, Britz HM, Bewer B, Zhouping W, Duke MJM, Doschak MR: Three dimensional mappingof strontium in bone by dual energy K-edge subtraction imaging. Phys Med Biol. 2012 Sep 21;57(18):5777-86
  • Lieverse, A. Cooper, D.M.L. Goriunovac, O.I. A rare naviculocuneiformI coalition from Bronze Age Siberia. International Journal of Paleopathology. Epublished 2012; Accepted Mar. 25th 2012.
  • Ashe, M.C. Gorman, E. Khan, K.M. Brasher, P.M. Cooper, D.M. McKay, H.A. and T. Liu-Ambrose, T. Does frequency of resistance training affecttibial cortical bone density in older women? A randomized controlled trial. Osteoporos Int. 2012 May 12.
  • Swanston, T. Varney, T. Coulthard, I. Feng, R. Bewer, B. Murphy, R. Hennig, C. and D. M. L. Cooper. Element localization inarchaeological bone using synchrotron radiation X-ray fluorescence:identification of biogenic uptake. Journal of Archaeological Science.
  • Britz, H.M. Jokihaara, J. Leppänen, O.V. Järvinen, T. and D.M.L. Cooper. The effects of immobilization on vascular canal orientation in rat cortical bone Journal of Anatomy 220 (1):67–76, Jan. 2012 (published online: 4 NOV 2011)
  • Zhu, N. Chapman, D. Cooper, D.M.L. Schreyer, D., and X. B. Chen. Diffraction enhanced imaging as a new methodology for low density scaffold visualization for soft tissue engineering application (TEC-2011-0102) Tissue Engineering. November 2011, 17(11): 1071-1080
  • Arhatari, B.D. Cooper, D.M.L.  Thomas, C.D.L. Clement, J.G. and A.G. Peele. Imaging 3D structure of secondary osteons in human cortical bone using phase retrieval tomography. 2011 Phys. Med. Biol. 56 5265.
  • Swanston, T. Carter, Y. Hopkins, C. Walker, E.G. and  D. M. L. Cooper. Developmental Fusion of the Malleus and Incus in a Late 19th-Century Case of Aural Atresia. International Journal of Osteoarchaeology. published online: 15 SEP 2011.
  • Stefan A.J., Kontulainen, S.A. Cooper, D.M.L. Lanovaz, J.L. and A.D.G. Baxter Jones. Maturational timing does not predict HSA estimated adult bone geometry at the proximal femur. Bone. 2011 Dec;49(6):1270-8. Epub 2011 Sep 5
  • Zhu, N. Li, M.G Chen, X.B. and Cooper D.M.L. Development of novel hybrid poly (l-lactide)/chitosan scaffolds using rapid freeze prototyping technique. Journal of Biofabrication. 2011 3 034105.
  • Stefan A.J., Kontulainen, S.A. Cooper, D.M.L. Lanovaz, J.L. and A.D.G. Baxter Jones. The Timing of Bone Mineral Density and Geometric Adaptation at the Proximal Femur from Childhood to Early Adulthood in Males and Females: A Longitudinal Study. J Bone Miner Res. 2011 Jul 19.
  • Cooper, D.M.L. Erickson, B.  Peele, A. Hannah, K. Thomas, C.D.L. and J.G. Clement. Visualization of 3D Osteon Morphology by Synchrotron Radiation Micro-CT.  J Anat. 2011 Jun 6.
  • Hennig C. and D.M.L. Cooper. The Relation between Standard Error of the Estimate and Sample Size of Histomorphometric Aging Methods  The American Journal of Physical Anthropology. Am J Phys Anthropol. 2011 May 17. doi: 10.1002/ajpa.21540. [Epub ahead of print]
  • Cooper, D.M.L. Bewer, B. Wiebe, S. Belev, G. Wysokinski, T.W. and D. Chapman. Preliminary Bone Imaging on the 05B1-1 Beamline at the Canadian Light Source: Exploration of Diffraction Enhanced Imaging.  Synchrotron Radiation News. March/April 2011. Vol.24, No.2, pp. 13-18.
  • Jackowski, S.A. Erlandson, M.C. Mirwald, R.L. Faulkner, R.A. Bailey, B.A. Kontulainen, S.A. Cooper, D.M.L. Lanovaz, J.L. and A.D.G. Baxter-Jones. Effect of maturational timing on bone mineral content accrual from childhood to adulthood: evidence from 15 years of longitudinal data. Bone. 2011 May 1;48(5):1178-85. Epub 2011 Feb 19.
  • 18.          Donaldson, F.E. Pankaj, P. Cooper, D.M.L. Thomas, C.D.L. Clement, J.G. and Hamish Simpson. Relating age and micro-architecture with apparent-level elastic constants: A muFE study of female cortical bone from the anterior femoral midshaft. Journal of Engineering in Medicine 2010. In Press. Nov. 2010.
  • Cooper, D.M.L. Bewer, B. Wiebe, S. Wysokinski, T.W. and D. Chapman. Diffraction Enhanced X-ray Imaging of the Distal Radius: A Novel Approach for Visualization of Trabecular Bone Architecture. Pictorial Essay. Canadian Association of Radiologists Journal.  2010 Jun 29. [Epub ahead of print]
  • 20.          Leppänen, O.V.  Sievänen, H.  Jokihaara, J.  Pajamäki, I.  Kannus, P. Cooper, D.M. and  T.L. Jarvinen.The Effects of Loading and Estrogen on Rat Bone Growth. J Appl Physiol. Jun;108(6):1737-44. Epub 2010 Apr 8.
  • Britz, H.M. Jokihaara, J. Leppänen, O.V. Järvinen, T. and D.M.L. Cooper. 3D Visualization and Quantification of Rat Cortical Bone Porosity Using a Desktop Micro-CT System: A Case Study in the Tibia. Journal of Microscopy. J Microsc. 2010 Oct;240(1):32-7.
  • Britz, H.M. Thomas, C.D.L. Clement, J.G. and D.M.L. Cooper. The relation of human femoral osteon geometry to age, sex, height and weight. Bone 2009 Jul;45(1):77-83. Epub 2009 Mar 19
  • Burrows, M. Cooper, D.M.L. Liu, D. and H.A. McKay.  Bone and muscle parameters of the tibia: agreement between the XCT 2000 and XCT 3000 instruments.  Journal of Clinical Densitometry. 2009 Apr-Jun;12(2):186-94. Epub 2008 Nov 11.
  • Goldman, H.M. McFarlin, S.C. Cooper, D.M.L. Thomas, C.D. and J. G. Clement. Ontogenetic patterning of cortical bone microstructure and geometry at the human midshaft femur. Journal of Anatomy 2009 Jan;292(1):48-64.
  • Manske, S.L. Liu-Ambrose, T. Cooper, D.M.L.  Guy, P. Forster, B.B. and H.A. McKay. Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction. Osteoporosis International  2009 Mar;20(3):445-53. Epub 2008 Jul 26.
  • Lazenby, R.A. Angus, S. Cooper, D.M.L. and B. Hallgrímsson. A 3D Micro-CT Study of Site Specific Variation in Trabecular Microarchitecture in the Human Second Metacarpal. Journal of Anatomy 2008 Dec;213(6):698-705.
  • Cooper, D.M.L. Ahamed, Y. Macdonald, H.M. and H.A McKay.  Characterizing Cortical Density in the Mid-Tibia: Intra-Individual Variation in Adolescent Girls and Boys. British Journal of Sport Medicine 2008 Aug;42(8):690-5. Epub 2008 Jul 17.
  • Goulet, G.C.  Hamilton, N. Cooper, D.M.L. Coombe, D. Martinuzzi R. and R. F. Zernicke. Influence of vascular porosity on fluid flow and nutrient transport in loaded cortical bone.  The Journal of Biomechanics 2008 Jul 19;41(10):2169-75. Epub 2008 Jun 4.
  • Ashe, M. Liu-Ambrose, T. Cooper, D.M.L.  Khan, K. and H.A. McKay. Muscle Power Contributes to Tibial Bone Strength in Older Women.  Osteoporosis International 2008 Dec;19(12):1725-32. Epub 2008 Jul 16.
  • MacDonald, H.M. Cooper, D.M.L. and H.A. McKay. A school-based physical activity intervention positively affects change in Imax in pre- and early pubertal boys.  Osteoporosis International 2008. Jan;20(1):61-70. Epub 2008 May 22.
  • Lazenby, R.A. Cooper, D.M.L. Angus, S. and B. Hallgrímsson. Articular Constraint, Handedness and Directional Asymmetry In the Human Second Metacarpal.  Journal of Human Evolution June;54(6):875-85.
  • Goulet, G.C. Cooper, D.M.L. Coombe, D. and R. F. Zernicke.  Influence of cortical canal architecture on lacunocanalicular pore pressure and fluid flow. Computer Methods in Biomechanics Biomedical Engineering 2008 Aug;11(4):379-87.
  • Cooper, D.M.L. Turinsky, A.L. Sensen, C.W. and B. Hallgrímsson.  Effect of Voxel Size on 3D Micro-CT Analysis of Cortical Bone Porosity.  Calcified Tissue International. 2007 Mar;80(3):211-9.
  • Cooper, D.M.L. Thomas, C.D.L. Clement, J.G.Turinsky, A.L. Sensen, C.W. and B. Hallgrímsson.  Age-Dependent Change in the 3D Structure of Cortical Porosity at the Human Femoral Midshaft.  Bone. 2007 Apr;40(4):957-65.
  • Sran, M.M. Khan, K.M. Cooper, D.M.L. Boyd, S.K. Zernicke, R.F. and T.R. Oxland.  Regional Trabecular Morphology Assessed by Micro-CT is Correlated with Failure of Aged Thoracic Vertebrae Under a Posteroanterior Load and may Determine the Site of Fracture. Bone 2007 Mar;40(3):751-7.