Dr. Anand Krishnan PhD

Postdoctoral Fellow, Division of Neurology, University of Alberta, Canada.

Postdoctoral Fellow, Clinical Neurosciences, University of Calgary, Canada.

PhD in Biotechnology (Area of research; Cancer Biology), Rajiv Gandhi Centre for Biotechnology, India.

Master of Pharmacy (Pharmacology), Manipal University, India.

Pharma R&D Experience;

• Orchid Chemicals and Pharmaceuticals Limited.
• Alembic Pharmaceuticals Limited.

Research Interests

Molecular mapping of nerve-tumor interface
There is compelling evidence that tumor and nerves interact and mutually support the growth of each other. However, the molecular players involved in this interaction are not well identified. Full characterization of the tumor-nerve interface and identification of the molecular players involved will reveal novel therapeutic targets for cancer and nerve regeneration. My lab focusses on mapping the tumor-nerve interface to develop molecular targets for cancer and neurodegenerative disorders.

Defining the roles of self-renewing resident macrophage in the nervous system
A population of macrophages in the peripheral nervous system self-renew independent of contribution from monocytes. However, the specific contribution of this population to the functioning of the nervous system is not understood. My lab is interested in studying the unique functions of this population in nervous system homeostasis and disorders.

 

Selected Publications

• Poitras TM, Komirishetty P, Areti A, Larouche M, Krishnan A, Chandrasekhar A, Munchrath E, Zochodne DW. Manipulation of the Myc Interactome to Enhance Nerve Regeneration in a Murine Model. Ann Neurol. 2024 May 31. doi: 10.1002/ana.26950.
• Bautista M, Katselis GS, Chowdhury B, Chumala P, Mahendra R, Desai P, Hall J, Kalyaanamoorthy S, Krishnan A*. Comparative proteomics analysis of growth-primed adult dorsal root ganglia reveals key molecular mediators for peripheral nerve regeneration. eNeuro 2023 Jan 5;10(1): ENEURO.0168-22.2022.
• Sivakumar B, Krishnan A*. Mesencephalic astrocyte-derived neurotrophic factor (MANF): An emerging therapeutic target for neurodegenerative disorders. 2023 Mar 28;12(7):1032. doi: 10.3390/cells12071032.
• Krishnan A, Areti A, Komirishetty P, Chandrasekhar A, Cheng C, Zochodne DW. Survival of compromised adult sensory neurons involves macrovesicular formation. Cell Death Discov. 2022 Nov 24;8(1):462.
• Elhasasna H, Khan R, Bhanumathy KK, Vizeacoumar FS, Walke P, Bautista M, Dahiya DK, Miranda V, Patel H, Balagopal A, Alli N, Krishnan A, Freywald A, Vizeacoumar FJ. (2022). A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers. Cells 2022 Jul 20;11(14):2246.
• Krishnan A, Dwivedi S, Chandrasekhar A, Areti A, Zochodne D. In vitro priming response in dorsal root ganglia partially mimics injury-driven pre-conditioning response and reprograms neurons for enhanced outgrowth. Mol Cell Neurosci. 2021 Jan; 110:103573.
• Dwivedi S, Bautista M, Shrestha S, Elhasasna H, Chaphekar T, Vizeacoumar F, Krishnan A*. (2021). Sympathetic signaling facilitates progression of neuroendocrine prostate cancer. Cell Death Discov. 7(1): 364.
• Dwivedi S, Krishnan A*. Neural invasion: a scenic trail for the nervous tumor and hidden therapeutic opportunity. Am J Cancer Res. 2020;10(8):2258-2270.
• Bautista M and Krishnan A*. The Autonomic Regulation of Tumor Growth and the Missing Links. Front Oncol. 2020 May 13; 10:744.

 

For full list of publications, please visit,

https://scholar.google.ca/citations?hl=en&tzom=360&user=Q-2IjjoAAAAJ

 

Chapter contributions

• Krishnan A*, Verge VMK, Zochodne DW. Hallmarks of peripheral nerve injury and regeneration. Handb Clin Neurol. 2024; 201: 1-17. Elsevier, Ed. Collin Chalk.
• Krishnan, A*. (2022). Tumor-Nerve Interface: An Emerging Therapeutic Intervention Point for Solid Cancers. In: Interdisciplinary Cancer Research. Springer, Cham. https://doi.org/10.1007/16833_2022_35
• Krishnan, A*. (2022). Neuroimmune Crosstalk in the Tumor Microenvironment. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_92-1

 

Funding

• NSERC
• Cancer Research Society
• CIHR Institute of Cancer Research
• The Breast Cancer Society of Canada
• The Prostate Cancer Fight Foundation and the Ride for Dad
• Saskatchewan Health Research Foundation (SHRF)
• College of Medicine