Dr. Juan Pablo (JP) Appendino MD, FRCPC, CSCN (EEG), FAES

Dr Juan Pablo Appendino is a Paediatric Neurologist – Epileptologist at Jim Pattison Children’s Hospital in Saskatoon, Saskatchewan, Canada. He is the Pediatric Neurology Division Head. He is a Professor in the Department of Pediatrics in the School of Medicine at the University of Saskatchewan. He enjoys education having created and lead the Neo-NERd Lat-Am through the Neonatal Brain Society (NBS) and is the leader of the evaluation section in the Canadian Epilepsy Teaching Network (CETN) in the Canadian League Against Epilepsy (CLAE). He is the Past-President of the Canadian Society of Clinical Neurophysiologists (CSCN) and a current examiner of the Canadian EEG examination. Dr Appendino is the former leader of the Drug and Therapeutics Committee at the CLAE, and a current Board Member of the “Academia Ibero-Americana de Neurología Pediátrica” (AINP).

Dr. Appendino is actively involved in medical education at the pre- and post-graduate level, particularly in epilepsy. He contributes to national and international teaching initiatives through the CLAE, NeoNERD-LatAm (NBS), AINP, and has published work on fostering epilepsy education in Canada.

Dr. Appendino's main clinical-research interest includes EEG-Trends use in neuro-critical monitoring in pediatrics, drug-resistant epilepsy, genetic epilepsy, epilepsy surgery, ketogenic diet, and autism-epilepsy. He has published more than 50 peer-reviewed scientific articles and guidelines, book chapters, and edited a handbook of antiseizure medications for residents and trainees and has mentored several trainees.

His research explores many aspects of epilepsy and genetic causes as well as epilepsy treatment and management, including neuromonitoring, epilepsy surgery and medical management. He also enjoys exploring other related topics in Pediatric Neurology as neuroinflammation and neuroinfectious disorders.

Identification of a Second-Hit Brain Somatic DEPDC5 Variant Supports Causality of a DEPDC5 Germline Variant of Uncertain Significance. Time for a Classification Update?

Alsayed A, Hakim Z, Merrikh D, Khanbabaei M, Kaur N, Hader W, Soule T, Ashtiani S, Polanco-Tovar G, Scantlebury M, Rahi H, Cao Y, Chan JA, Appendino JP, Pfeffer G, Au PYB, Klein KM.Am J Med Genet A. 2025 Jul 31:e64204. doi: 10.1002/ajmg.a.64204. Online ahead of print.PMID: 40742146

 

Chikungunya virus infection: A scoping review highlighting pediatric systemic and neurologic complications.

Huerta Albarrán R, Weber A, Avilés Robles M, Appendino JP.Semin Pediatr Neurol. 2025 Jul;54:101213. doi: 10.1016/j.spen.2025.101213. Epub 2025 Jun 26.PMID: 40701690

 

Successful Treatment of Pediatric Neurosarcoidosis With Corticosteroids, Infliximab, and Methotrexate.

Sun R, Bakker A, Stevenson R, Wei XC, Woodward K, Appendino JP.Pediatr Neurol. 2025 Sep;170:110-112. doi: 10.1016/j.pediatrneurol.2025.06.024. Epub 2025 Jun 30.PMID: 40680458 No abstract available.

 

[Real-life study with pharmaceutical cannabidiol in refractory epilepsy].

Di Giuseppe LA, Appendino JI, García MDC, Alvarez KE, Buela G, Burgos MA, Posadas-Martínez ML, Puga MC.Rev Fac Cien Med Univ Nac Cordoba. 2025 Mar 31;82(1):110-126. doi: 10.31053/1853.0605.v82.n1.45350.PMID: 40163830 Free PMC article. Spanish.

 

Cortical Stimulation for brain mapping and seizure stimulation, pediatric practices throughout Canada: A national survey and systematic literature review.

Maltseva M, Appendino JP, Cabounova P, Andrade A, Kregel M, Hadjinicolaou A, Weil AG, Jain P, Donner E, Borlot F, Dufresne D, Huh L, Liu N, Myers KA, Jacobs J.Neurophysiol Clin. 2025 Apr;55(2):103043. doi: 10.1016/j.neucli.2025.103043. Epub 2025 Feb 7.PMID: 39922024 Free article.

 

EEG Training in the Context of Competency-Based Learning: When Is Enough, Actually Enough?

D'Onofrio G, Reid AY, Ramachandrannair R, Appendino JP, Jones K, Kobayashi E, Fantaneanu T, Ikeda KM, Striano P, Datta A, Bui E.Can J Neurol Sci. 2025 Jan 24:1-2. doi: 10.1017/cjn.2025.8. Online ahead of print.PMID: 39849887 No abstract available.

 

Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy.

Mascarenhas R, Merrikh D, Khanbabaei M, Kaur N, Ghaderi N, Maroilley T, Liu Y, Soule T, Appendino JP, Jacobs J, Wiebe S; Calgary Comprehensive Epilepsy Program Collaborators; Hader W, Pfeffer G, Tarailo-Graovac M, Klein KM.Epilepsia. 2025 Apr;66(4):1234-1249. doi: 10.1111/epi.18251. Epub 2025 Jan 3.PMID: 39751777 Free PMC article.

 

[Non-surgical treatment of refractory epilepsy in children].

Appendino JP, Salazar CI.Medicina (B Aires). 2024 Sep;84 Suppl 3:63-68.PMID: 39331778 Free article. Review. Spanish.

 

Superior lesion detection on 3D FSE T1WI with magnetization transfer and CHESS preparation pulses in children with focal epilepsy: Preliminary results.

Wei XC, Assis Z, Sherriff M, Hader WJ, Appendino JP.Epileptic Disord. 2024 Dec;26(6):840-846. doi: 10.1002/epd2.20271. Epub 2024 Aug 16.PMID: 39150433 Free PMC article.

 

Channelopathies in epilepsy: an overview of clinical presentations, pathogenic mechanisms, and therapeutic insights.

Ng AC, Chahine M, Scantlebury MH, Appendino JP.J Neurol. 2024 Jun;271(6):3063-3094. doi: 10.1007/s00415-024-12352-x. Epub 2024 Apr 12.PMID: 38607431 Review.