Picture of Dr. Barry Ziola

Dr. Barry Ziola Faculty, Pathology and Laboratory Medicine

About Dr. Barry Ziola

Academic Interests

Medical Microbiology, especially medical virology

What are your research interests?

Genetic expression during growth of lactic acid bacteria in various environments. The model system used is growth in beer due to the relatively harsh environment posed by this medium (acidic pH of 3.8-4.2, lack of nutrients due to yeast using abundant sugars for fermentation, low oxygen level, high carbon dioxide level giving pressure, and the antimicrobial effects of ethanol and hop compounds). Rapid detection of microbes in industry, food and human or animal health settings.

What are your current projects?

Analysis of global and specific gene transcription during growth of lactobacilli and pediococci in beer or modeled components of beer (e.g., hops or ethanol added to minimal medium). Assembly of the genome of Lactobacillus backii. Derivation of plasmid variants of various beer-spoilage bacteria and analysis of their ability to grow in beer. Analysis of biofilm deposition on stainless steel for lactic acid bacteria growing in beer.

How should/can a trainee contact you to inquire regarding research?

Phone (306) 966-4030 to book a meeting time.

Clinical Interests

  • Diagnosis of autoimmune disease

Selected Publications

Papers in Referred Journals
  • Item (85) J. Bergsveinson, V. Pittet and B. Ziola, 2012. RT-qPCR analysis of putative beer-spoilage gene expression during growth of Lactobacillus brevis BSO 464 and Pediococcus claussenii ATCC BAA-344T in beer. Appl. Microbiol. Biotechnol. 96:461-470. DOI 10.1007/s00253-012-4334-3.

Papers in Non-Referred Journals:
Published:

  • Item (2) B. Ziola. Getting into medicine at the U. of S. Invited article for the special issue on Health Care in RuralCouncillor (published by the Saskatchewan Association of Rural Municipalities). December, 2011/January, 2012, pages 16-17.

Contributed Papers In Published Conference Proceedings And Abstracts:

Item (111) J. Bergsveinson, N. Baecker, V. Pittet and B. Ziola, 2013. Effect of plasmid loss on the beer-spoilage ability, hops tolerance and antibiotic resistance of Lactobacillus brevis BSO 464. 63rd Annual Meeting of the Canadian Society of Microbiologists. June 17- 20, Ottawa ON (both poster and oral presentation).

Item (110) V. Pittet, E. Ewen and B. Ziola, 2013. Pedicoccus claussenii plasmid copy number when grown in beer. 73nd Annual Meeting of the American Society of Brewing Chemists. May 19-22, Tucson AZ (oral presentation).

Item (109) H. Neufeld, D. Pilavdzic, S. Kalssen, B. Gilks, J. Garratt, B. Ziola, C. Cheung, J. Krahn and E. Torlakovic, 2013. Improving class II immunohistochemical tests quality: Levey Jennings quality control charts monitoring of cell line-based calibration models and positive controls through image analysis. International Forum on Quality and Safety in Health Care. April 16-19, London, England (poster presentation).

Item (108) N. Baecker, J. Bergsveinson, V. Pittet and B. Ziola, 2013. Effect of plasmid loss on the beer-spoilage ability of Lactobacillus brevis BSO 464. 20th Life and Health Sciences Research Conference; University of Saskatchewan (poster presentation).

Item (107) H. Neufeld, D. Pilavdzic, J. Garratt, B. Gilks, C. Cheung, B. Ziola, R. Berendt, J. Krahn, S. Carlsen and E. Torlakovic, 2013. Ranking of individual laboratory performance in immunohistochemistry proficiency testing using digital image analysis. United States and Canada Academy of Pathology. March 2-8, Baltimore MD (poster presentation).

Item (106) H. Neufeld, R. Berendt, D. Pilavdzic, B. Ziola, J. Krahn, C. Cheung, B. Gilks, J. Garratt, S. Carlsen and E. Torlakovic, 2013. Feasibility of Levey-Jennings quality control charts for monitoring estrogen receptor (ER) and progesterone receptor (PR) immunohistochemistry testing. Ibid. (poster presentation).

Item (105) H. Neufeld, R. Berendt, D. Pilavdzic, B. Perez-Ordonez, B. Ziola, B. Gilks, J. Garratt, C. Cheung, J. Krahn, S. Carlsen and E. Torlakovic, 2013. Application of image analysis for daily monitoring of positive controls in clinical immunohistochemistry. Ibid. (poster presentation).

Item (104) V. Pittet, T.G. Phister and B. Ziola, 2012. Pediococcus claussenii genetic expression during growth in beer assessed by transcriptome sequencing (RNA-seq). World Brewing Congress 2012, July 28 – August 1, Portland, OR (oral presentation)

Item (103) J. Bergsveinson, V. Pittet and B. Ziola, 2012. Quantitative real-time PCR analysis of putative beer-spoilage associated genes in Pediococcus claussenii and Lactobacillus brevis. Ibid. (poster presentation).

Item (102) E. Ewen, V. Pittet and B. Ziola, 2012. Effect of plasmid loss and the beer-spoiling phenotype of Pediococcus claussenii ATCC BAA-344T. Ibid. (poster presentation).

Item (101) B.R. Bushell, V. Pittet and B. Ziola, 2012. Optimizing hops gradient plates for assessing bacterial beer-spoilage potential. Ibid. (poster presentation).