Picture of Peter Bretscher

Peter Bretscher Professor Biochemistry, Microbiology & Immunology

Rm 6B55 Health Sciences

Research Area(s)

  • Mechanisms responsible for self-nonself discrimination and immune class determination
  • Immune responses in autoimmunity, to tumours, and in chronic infectious diseases, and strategies of vaccination


Department of Biochemistry, Microbiology and Immunology
College of Medicine, University of Saskatchewan


Overview of this Web Profile

            The link to the web site, at the bottom of this page, has four sections. The first provides a brief scientific autobiography, describing my aspirations, and how I came to do some science. I also reflect on how the scientific culture has changed in the 50 years that I have been engaged in science.

            The second describes the books I have written and am writing. I explain how I came to write them, and provide some comments by others on the books published.

The third section relates to my best-known scientific contribution, The Two Signal Model of Lymphocyte Activation, published with Melvin Cohn in Science, in 1970, when I was a Postdoctoral Fellow in Cohn’s lab. 

The fourth section lists our more significant scientific papers, with a description of why I have thought them to be significant. This description includes the scientific context in which the reasearch was carried out. I do hope some who read this section will be stimulated by the ideas expressed. I would like to hear from those who enjoy these ideas, or are skeptical of them on either conceptual or observational grounds. I would be delighted if this description gave rise to scientific discussion.