Picture of Dr. Lisa Kalynchuk

Dr. Lisa Kalynchuk BSc, MSc, PhD Faculty

About Dr. Lisa Kalynchuk

Dr. Lisa Kalynchuk is a tenured Full Professor in the Department of Medicine and the Interim Associate Dean, Interdisciplinary Health Research for the Council of Health Sciences Deans. She recently completed two terms as a Canada Research Chair in Behavioral Neuroscience. Lisa was previously a faculty member in the Department of Psychology at the University of Saskatchewan (from 2004-13) and in the Department of Psychology and Neuroscience at Dalhousie University (from 1999-2004).

Lisa’s research takes a translational approach to issues in mental health and brain disease. Her current interests include understanding the effect of chronic stress on brain function, developing biomarkers for diagnosis and treatment responsivity in depression, and designing treatment options for the psychiatric complications associated with epilepsy. She has a particular interest in building bridges between animal model-based research and patient-orientated research. She has obtained about 5.7 million dollars in research funding and authored more than 210 published papers and conference presentations. She has also been very active in the broader research community, serving on the editorial board of several journals in her field and on grant selection committees for NSERC, CIHR, Brain Canada, the Saskatchewan Health Research Foundation, the Nova Scotia Health Research Foundation, and the Michael Smith Foundation for Health Research.

Education

1990            B.Sc.          Psychology, University of Alberta
1992            M.A.          Behavioral Neuroscience, University of British Columbia
1996            Ph.D.          Behavioral Neuroscience, University of British Columbia
1997-99      Post-Doc    Department of Neurology & Neurosurgery, McGill University

Selected Awards

1999-04      NSERC University Faculty Award
2000            National Alliance for Research on Schizophrenia and Depression (NARSAD - USA)
2000            Young Investigator Award - Selected by The Globe and Mail as one of the eight top Canadian Leaders in the field of Medicine under the age of 35 (July 1 insert on medical research)
2004-09     Canada Research Chair in Behavioural Neuroscience (CIHR- Tier II)
2009-14     Canada Research Chair in Behavioural Neuroscience (CIHR- Tier II - renewal)

Selected Publications

  • Lussier, A.L., Romay-Tallon, R., Caruncho, H.J., & Kalynchuk, L.E. (2013). Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress. Neuroscience, 231, 38-48.
  • Fournier, N.M., Botterill, J.J., Marks, W.N., Guskjolen, A.J. & Kalynchuk, L.E. (2013). Impaired recruitment of seizure-generated neurons into functional memory networks of the adult dentate gyrus following long-term amygdala kindling. Experimental Neurology, 244, 96-104.
  • Lussier, A.L., Lebedeva, K., Fenton, E.Y., Guskjolen, A., Caruncho, H.J., & Kalynchuk, L.E. (2013). The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus. Neuropharmacology, 71, 174-183.
  • Botterill, J.J., Fournier, N.M., Guskjolen, A.J., Lussier, A.L., Marks, W.N., & Kalynchuk, L.E. (2014). Amygdala kindling disrupts both cued and contextual fear conditioning and alters Fos protein expression throughout the limbic brain. Neuroscience, 265, 158-171.
  • Rivera-Baltanás, T., Olivares, J.M., Martínez-Villamarín, J.R., Fenton, E.Y., Kalynchuk, L.E., & Caruncho, H.J. (2014). Serotonin 2A receptor clustering in peripheral lymphocytes is altered in major depression and may be a biomarker of therapeutic efficacy. Journal of Affective Disorders, 163, 47-55.
  • Botterill, J.J., Guskjolen, A., Marks, W.N., Caruncho, H.J., & Kalynchuk, L.E. (2015). Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and the Y2 receptor. Brain Structure and Function, 220, 3641-3655.
  • Romay-Tallon, R., Rivera-Baltanas, T., Kalynchuk, L.E., & Caruncho, H.J. (2015). Differential effects of corticosterone on the co-localization of reelin and neuronal nitric oxide synthase in the adult dentate gyrus in wild type and heterozygous reeler mice. Brain Research, 1594, 274-283.
  • Marks, W.N., Fenton, E.Y., Guskjolen, A.J., & Kalynchuk, L.E. (2015). The effect of repeated corticosterone on fear learning and memory depends on dose and the testing protocol. Neuroscience, 289C, 324-333.
  • Fenton, E.Y., Fournier, N.M., Lussier, A.L., Romay-Tallon, R., Caruncho, H.J., and Kalynchuk, L.E. (2015). Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 60, 52-59.
  • Botterill, J.J., Brymer, K., Caruncho, H.J., & Kalynchuk, L.E. (2015). Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memory. Epilepsy & Behavior, 47, 83-92.
  • Rivera-Baltanas, T., Agis-Balboa, R.C., Romay-Tallon, R., Kalynchuk, L.E., Olivares. J.M., & Caruncho, H.J. (2015). Serotonin transporter clustering in blood lymphocytes predicts the outcome on anhedonia scores in naïve depression patients treated with antidepressant medication. Annals of General Psychiatry, 14, 45.
  • Caruncho, H.J., Brymer, K.J., Romay-Tallon, R., Mitchell, M.A, Rivera-Baltanas, T., Botterill, J.J., Olivares, J.M., & Kalynchuk, L.E. (2016). Reelin-related disturbances in depression: Implications for translational studies. Frontiers in Cellular Neuroscience, 10, 48.
  • Botterill, J.J., Nogovitsyn, N., Caruncho, H.J., & Kalynchuk, L.E. (2016). Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain sites. Journal of Comparative Neurology, submitted.
  • Marks, M.N. & Kalynchuk, L.E. (2016). Repeated corticosterone enhances acquisition and recall of trace fear conditioning. Neuroscience Letters, submitted.